Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis
Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Anti-reflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to ev...
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| Veröffentlicht in: | International journal of surgery (London, England) England), 2024-08 |
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| container_title | International journal of surgery (London, England) |
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| creator | Liu, Yuheng Huang, Junfeng Zhong, Shuxin Zheng, Ziwen Xu, Zhixing Zhou, Dongda Xie, Shuojia Lin, Zikai Li, Shiyue Chen, Ruchong |
| description | Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Anti-reflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to evaluate the improvement in gastroesophageal-related cough and other reflux symptoms following anti-reflux procedures.
A systematic review was performed by searching PubMed, Embase, and Cochrane Library. All observational studies reporting the improvement of GERC and other reflux symptoms after the anti-reflux procedures. Data were extracted and pooled using a random effects model to assess the overall effect size and heterogeneity between studies. We found that anti-reflux surgery has some clear benefits for common reflux-related symptoms.
Fifty-nine eligible studies with 7431 patients with GERD were included in this study. The pooled cough remission rate was 80.0% (95%CI 75.4-84.2) and the mean time of follow up was 35.8 months. Anti-reflux surgery significantly improved overall reflux-related symptom scores (all P |
| doi_str_mv | 10.1097/JS9.0000000000001998 |
| format | Article |
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A systematic review was performed by searching PubMed, Embase, and Cochrane Library. All observational studies reporting the improvement of GERC and other reflux symptoms after the anti-reflux procedures. Data were extracted and pooled using a random effects model to assess the overall effect size and heterogeneity between studies. We found that anti-reflux surgery has some clear benefits for common reflux-related symptoms.
Fifty-nine eligible studies with 7431 patients with GERD were included in this study. The pooled cough remission rate was 80.0% (95%CI 75.4-84.2) and the mean time of follow up was 35.8 months. Anti-reflux surgery significantly improved overall reflux-related symptom scores (all P<0.001). We also assessed the rate of remission of other reflux symptoms. The pooled heartburn remission rate was 87.7% (95%CI 82.3-92.2) and the pooled regurgitation remission rate was 91.2%(95%CI 87.8-94.1).
Anti-reflux procedures significantly improve gastroesophageal-related cough and other reflux symptoms. These findings support the use of anti-reflux procedures as a viable treatment option for patients with GERD symptoms. Further research is needed to identify predictors of success and to optimize patient selection for anti-reflux procedures.</description><identifier>ISSN: 1743-9159</identifier><identifier>EISSN: 1743-9159</identifier><identifier>DOI: 10.1097/JS9.0000000000001998</identifier><identifier>PMID: 39206849</identifier><language>eng</language><publisher>United States</publisher><ispartof>International journal of surgery (London, England), 2024-08</ispartof><rights>Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-8208-3687</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39206849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Yuheng</creatorcontrib><creatorcontrib>Huang, Junfeng</creatorcontrib><creatorcontrib>Zhong, Shuxin</creatorcontrib><creatorcontrib>Zheng, Ziwen</creatorcontrib><creatorcontrib>Xu, Zhixing</creatorcontrib><creatorcontrib>Zhou, Dongda</creatorcontrib><creatorcontrib>Xie, Shuojia</creatorcontrib><creatorcontrib>Lin, Zikai</creatorcontrib><creatorcontrib>Li, Shiyue</creatorcontrib><creatorcontrib>Chen, Ruchong</creatorcontrib><title>Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis</title><title>International journal of surgery (London, England)</title><addtitle>Int J Surg</addtitle><description>Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Anti-reflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to evaluate the improvement in gastroesophageal-related cough and other reflux symptoms following anti-reflux procedures.
A systematic review was performed by searching PubMed, Embase, and Cochrane Library. All observational studies reporting the improvement of GERC and other reflux symptoms after the anti-reflux procedures. Data were extracted and pooled using a random effects model to assess the overall effect size and heterogeneity between studies. We found that anti-reflux surgery has some clear benefits for common reflux-related symptoms.
Fifty-nine eligible studies with 7431 patients with GERD were included in this study. The pooled cough remission rate was 80.0% (95%CI 75.4-84.2) and the mean time of follow up was 35.8 months. Anti-reflux surgery significantly improved overall reflux-related symptom scores (all P<0.001). We also assessed the rate of remission of other reflux symptoms. The pooled heartburn remission rate was 87.7% (95%CI 82.3-92.2) and the pooled regurgitation remission rate was 91.2%(95%CI 87.8-94.1).
Anti-reflux procedures significantly improve gastroesophageal-related cough and other reflux symptoms. These findings support the use of anti-reflux procedures as a viable treatment option for patients with GERD symptoms. Further research is needed to identify predictors of success and to optimize patient selection for anti-reflux procedures.</description><issn>1743-9159</issn><issn>1743-9159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpNUE1PwzAUixCIjcE_QChHLh1J06553NA0vjSJA3CuXtOXLqhfNC3Qf8-AIc0X25Ltgxk7l2IuBSRXj88wF3uQAPqATWUSqQBkDId7esJOvH8TIhJa6mM2URCKhY5gyvzKWmfQjBzrnHu01I-8sVvXu6AjWw5f3A9dQd3IXc0L9H3XkG_aDRaE5TZSYk85N81QbK45cj_6nirsneEdfTj6_B2uqMcAayxH7_wpO7JYejrb8Yy93q5elvfB-unuYXmzDlopQh1kOSHIbJGTUVoIFUoFWay0kRa1CMnGkjAHLVUS2yzUUaLQQAg6ERlgJNWMXf7ttl3zPpDv08p5Q2WJNTWDT5UASCD5Kc7YxS46ZBXladu5Crsx_T9KfQOP8WzH</recordid><startdate>20240830</startdate><enddate>20240830</enddate><creator>Liu, Yuheng</creator><creator>Huang, Junfeng</creator><creator>Zhong, Shuxin</creator><creator>Zheng, Ziwen</creator><creator>Xu, Zhixing</creator><creator>Zhou, Dongda</creator><creator>Xie, Shuojia</creator><creator>Lin, Zikai</creator><creator>Li, Shiyue</creator><creator>Chen, Ruchong</creator><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8208-3687</orcidid></search><sort><creationdate>20240830</creationdate><title>Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis</title><author>Liu, Yuheng ; Huang, Junfeng ; Zhong, Shuxin ; Zheng, Ziwen ; Xu, Zhixing ; Zhou, Dongda ; Xie, Shuojia ; Lin, Zikai ; Li, Shiyue ; Chen, Ruchong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1028-bdea91b6dec380032139b538c1fa802ef51ead981375fb28473ac929870b9a413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Yuheng</creatorcontrib><creatorcontrib>Huang, Junfeng</creatorcontrib><creatorcontrib>Zhong, Shuxin</creatorcontrib><creatorcontrib>Zheng, Ziwen</creatorcontrib><creatorcontrib>Xu, Zhixing</creatorcontrib><creatorcontrib>Zhou, Dongda</creatorcontrib><creatorcontrib>Xie, Shuojia</creatorcontrib><creatorcontrib>Lin, Zikai</creatorcontrib><creatorcontrib>Li, Shiyue</creatorcontrib><creatorcontrib>Chen, Ruchong</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgery (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Yuheng</au><au>Huang, Junfeng</au><au>Zhong, Shuxin</au><au>Zheng, Ziwen</au><au>Xu, Zhixing</au><au>Zhou, Dongda</au><au>Xie, Shuojia</au><au>Lin, Zikai</au><au>Li, Shiyue</au><au>Chen, Ruchong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis</atitle><jtitle>International journal of surgery (London, England)</jtitle><addtitle>Int J Surg</addtitle><date>2024-08-30</date><risdate>2024</risdate><issn>1743-9159</issn><eissn>1743-9159</eissn><abstract>Gastroesophageal reflux disease (GERD) is a prevalent condition that manifests a spectrum of symptoms, including gastroesophageal-related cough (GERC). Anti-reflux procedures have been employed to alleviate these symptoms, yet their efficacy varies. This systematic review and meta-analysis aim to evaluate the improvement in gastroesophageal-related cough and other reflux symptoms following anti-reflux procedures.
A systematic review was performed by searching PubMed, Embase, and Cochrane Library. All observational studies reporting the improvement of GERC and other reflux symptoms after the anti-reflux procedures. Data were extracted and pooled using a random effects model to assess the overall effect size and heterogeneity between studies. We found that anti-reflux surgery has some clear benefits for common reflux-related symptoms.
Fifty-nine eligible studies with 7431 patients with GERD were included in this study. The pooled cough remission rate was 80.0% (95%CI 75.4-84.2) and the mean time of follow up was 35.8 months. Anti-reflux surgery significantly improved overall reflux-related symptom scores (all P<0.001). We also assessed the rate of remission of other reflux symptoms. The pooled heartburn remission rate was 87.7% (95%CI 82.3-92.2) and the pooled regurgitation remission rate was 91.2%(95%CI 87.8-94.1).
Anti-reflux procedures significantly improve gastroesophageal-related cough and other reflux symptoms. These findings support the use of anti-reflux procedures as a viable treatment option for patients with GERD symptoms. Further research is needed to identify predictors of success and to optimize patient selection for anti-reflux procedures.</abstract><cop>United States</cop><pmid>39206849</pmid><doi>10.1097/JS9.0000000000001998</doi><orcidid>https://orcid.org/0000-0001-8208-3687</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Efficacy and safety of anti-reflux surgery in gastroesophageal-related cough: a systematic review and meta-analysis |
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