T-cell Large Granular Lymphocytic Leukemia with a STAT3 mutation successfully treated with Cord Blood Transplantation
A 64-year-old woman presented with agranulocytosis, anemia, and bacteremia, leading to a diagnosis of T-cell large granular lymphocytic leukemia (T-LGLL). A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphami...
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| Veröffentlicht in: | Internal Medicine 2024, pp.4163-24 |
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| creator | Tokunaga, Yoshihiro Nakamura, Yukinori Ando, Taishi Katsuki, Kensaku Sakai, Kohei Fujioka, Yuka Nono, Shota Sasaki, Takahiro Yamamoto, Kaoru Akiyama, Masaru Kawakami, Fumihiro Kawakami, Toru Ishida, Fumihiro Ohta, Yasuharu Yujiri, Toshiaki |
| description | A 64-year-old woman presented with agranulocytosis, anemia, and bacteremia, leading to a diagnosis of T-cell large granular lymphocytic leukemia (T-LGLL). A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphamide and prednisolone did not improve her condition, but serious infections were observed. The patient underwent cord blood transplantation (CBT) after preconditioning with fludarabine, busulfan, and total body irradiation, yielding a STAT3 Y640F variant disappearance, based on allele-specific quantitative polymerase chain reaction (AS-qPCR). In this case, CBT is a promising refractory T-LGLL treatment option, and the STAT3 Y640F variant AS-qPCR is a T-LGLL activity marker. |
| doi_str_mv | 10.2169/internalmedicine.4163-24 |
| format | Article |
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A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphamide and prednisolone did not improve her condition, but serious infections were observed. The patient underwent cord blood transplantation (CBT) after preconditioning with fludarabine, busulfan, and total body irradiation, yielding a STAT3 Y640F variant disappearance, based on allele-specific quantitative polymerase chain reaction (AS-qPCR). 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Med.</addtitle><date>2024-08-28</date><risdate>2024</risdate><spage>4163-24</spage><pages>4163-24-</pages><issn>0918-2918</issn><issn>1349-7235</issn><eissn>1349-7235</eissn><abstract>A 64-year-old woman presented with agranulocytosis, anemia, and bacteremia, leading to a diagnosis of T-cell large granular lymphocytic leukemia (T-LGLL). A molecular analysis identified a signal transducer and activator of transcription 3 (STAT3) Y640F variant. Initial treatment with cyclophosphamide and prednisolone did not improve her condition, but serious infections were observed. The patient underwent cord blood transplantation (CBT) after preconditioning with fludarabine, busulfan, and total body irradiation, yielding a STAT3 Y640F variant disappearance, based on allele-specific quantitative polymerase chain reaction (AS-qPCR). In this case, CBT is a promising refractory T-LGLL treatment option, and the STAT3 Y640F variant AS-qPCR is a T-LGLL activity marker.</abstract><cop>Japan</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>39198169</pmid><doi>10.2169/internalmedicine.4163-24</doi><oa>free_for_read</oa></addata></record> |
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| subjects | allele-specific quantitative PCR cord blood transplantation signal transducer and activator of transcription 3 (STAT3) T-cell large granular lymphocytic leukemia |
| title | T-cell Large Granular Lymphocytic Leukemia with a STAT3 mutation successfully treated with Cord Blood Transplantation |
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