Efficacy, safety, and pharmacokinetics of inhaled treprostinil in Japanese patients with pulmonary hypertension associated with interstitial lung disease

The INCREASE trial, conducted in the United States, showed that inhaled treprostinil improved exercise capacity in pulmonary hypertension associated with interstitial lung disease (PH-ILD). However, hemodynamic and pharmacokinetic measurements were not performed in the trial. The objective of this t...

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Veröffentlicht in:	Respiratory investigation 2024-11, Vol.62 (6), p.980-986
Hauptverfasser:	Sakao, Seiichiro, Kondoh, Yasuhiro, Kinoshita, Hideyuki, Nishiyama, Osamu, Ogo, Takeshi, Tanabe, Nobuhiro, Minatsuki, Shun, Nakayama, Kazuhiko, Taniguchi, Yu, Takahashi, Kenta, Takatsu, Masahiro, Ogura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aged Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacokinetics Clinical trial East Asian People Epoprostenol - administration & dosage Epoprostenol - adverse effects Epoprostenol - analogs & derivatives Epoprostenol - pharmacokinetics Exercise Tolerance Female Hemodynamics Humans Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - etiology Interstitial lung disease Lung Diseases, Interstitial - drug therapy Male Middle Aged Prostacyclin Pulmonary hypertension Safety Treatment Outcome Vascular Resistance - drug effects
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