Design, synthesis, and biological evaluation of oridonin derivatives as novel NLRP3 inflammasome inhibitors for the treatment of acute lung injury

Acute lung injury (ALI) is a severe respiratory disorder closely associated with the excessive activation of the NLRP3 inflammasome. Oridonin (Ori), a natural diterpenoid compound, had been confirmed as a specific covalent NLRP3 inflammasome inhibitor, which was completely different from that of MCC...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-11, Vol.277, p.116760, Article 116760
Hauptverfasser:	Li, Mengting, Ma, Lingyu, Lv, Jiahao, Zheng, Zhe, Lu, Wenyu, Yin, Xunkai, Lin, Weijiang, Wang, Ping, Cui, Jian, Hu, Lihong, Liu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lung injury NLRP3 inflammasome NLRP3 inhibitors Oridonin Oridonin derivatives
Online-Zugang:	Volltext
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