Microbiome-derived indole-3-lactic acid reduces amyloidopathy through aryl-hydrocarbon receptor activation

•We identified three probiotic strains that significantly reduce amyloid-beta (Aβ) and prevent cognitive impairment in 5xFAD mice.•Lactobacillus reuteri is more abundant in healty human stool samples compared to those with mild cognitive impairment, suggesting its potential role in AD prevention.•In...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2024-11, Vol.122, p.568-582
Hauptverfasser:	Kim, Hyun, Lee, Eunkyung, Park, Mincheol, Min, Kyungchan, Diep, Yen N., Kim, Jinhong, Ahn, Hyeok, Lee, Eulgi, Kim, Sujeong, Kim, Yunjae, Kang, You Jung, Jung, Joon Hyung, Byun, Min Soo, Joo, Yanghyun, Jeong, Chanyeong, Lee, Dong Young, Cho, Hansang, Park, Hansoo, Kim, Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Cognitive function Indole Metabolomics Metagenomics Microbiome Neuroinflammation Transcriptomics
Online-Zugang:	Volltext
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