Inducing or enhancing protein-protein interaction to develop drugs: Molecular glues with various biological activity

Over the past two decades, molecular glues (MGs) have gradually attracted the attention of the pharmaceutical community with the advent of MG degraders such as IMiDs and indisulam. Such molecules degrade the target protein by promoting the interaction between the target protein and E3 ligase. In add...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-11, Vol.277, p.116756, Article 116756
Hauptverfasser:	Zhang, Rongyu, Zheng, Yirong, Xiang, Fengjiao, Zhou, Jinming
Format:	Artikel
Sprache:	eng
Schlagworte:	Degrader Development strategies Drug Development Humans Molecular glue Molecular Structure PPI stabilizer Protein Binding Protein-protein interaction Proteins - antagonists & inhibitors Proteins - chemistry Proteins - metabolism Proteolysis - drug effects
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