Nonlipogenic ABCA1 Inducers (NLAI) for Alzheimer's Disease Validated in a Mouse Model Expressing Human APOE3/APOE4

Therapeutics enhancing apolipoprotein (APOE) positive function are a priority, because is the major genetic risk factor for Alzheimer's disease (AD). The function of APOE, the key constituent of lipoprotein particles that transport cholesterol and lipids in the brain, is dependent on lipidation...

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Veröffentlicht in:	Journal of medicinal chemistry 2024-09, Vol.67 (17), p.15061-15079
Hauptverfasser:	Velma, Ganga Reddy, Laham, Megan S, Lewandowski, Cutler, Valencia-Olvera, Ana C, Balu, Deebika, Moore, Annabelle, Ackerman-Berrier, Martha, Rychetsky, Pavel, Penton, Christopher, Musku, Soumya Reddy, Annadurai, Anandhan, Sulaiman, Maha Ibrahim, Ma, Nina, J Thatcher, Gregory R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Animals Apolipoprotein E3 - genetics Apolipoprotein E3 - metabolism Apolipoprotein E4 - genetics Apolipoprotein E4 - metabolism ATP Binding Cassette Transporter 1 - genetics ATP Binding Cassette Transporter 1 - metabolism Disease Models, Animal Humans Liver X Receptors - agonists Liver X Receptors - metabolism Mice Mice, Transgenic Presenilin-1 - genetics Presenilin-1 - metabolism
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