Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(III) complex

Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(III) complex

We herein report a "Fight Aggregation with Aggregation" (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(III) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffol...

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Veröffentlicht in:Dalton transactions : an international journal of inorganic chemistry 2024-09, Vol.53 (36), p.14966-14970
Hauptverfasser: Zhou, Yuancun, Zhu, Jiacheng, Gao, Furong, Hu, Ming, Qian, Chengyuan, Wang, Xin, Wang, Xiaohui
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Aqueous solutions
Europium
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container_end_page 14970
container_issue 36
container_start_page 14966
container_title Dalton transactions : an international journal of inorganic chemistry
container_volume 53
creator Zhou, Yuancun
Zhu, Jiacheng
Gao, Furong
Hu, Ming
Qian, Chengyuan
Wang, Xin
Wang, Xiaohui
description We herein report a "Fight Aggregation with Aggregation" (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(III) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.
doi_str_mv 10.1039/d4dt02188f
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subjects Aqueous solutions
Europium
title Fighting fire with fire: remodeling Aβ aggregation with H-aggregates of a europium(III) complex
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