Supramolecular materials constructed from synthetic glycopeptides via aqueous self-assembly and their bioapplications in immunotherapy
Synthetic glycopeptides capable of self-assembly in aqueous environments form a range of supramolecular nanostructures, such as nanoparticles and nanofibers, owing to their amphiphilic nature and the diverse structures of the saccharides introduced. These glycopeptide-based supramolecular materials...
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| Veröffentlicht in: | Organic & biomolecular chemistry 2024-09, Vol.22 (36), p.7287-7306 |
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| container_title | Organic & biomolecular chemistry |
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| creator | Sugiura, Shintaro Ikeda, Masato |
| description | Synthetic glycopeptides capable of self-assembly in aqueous environments form a range of supramolecular nanostructures, such as nanoparticles and nanofibers, owing to their amphiphilic nature and the diverse structures of the saccharides introduced. These glycopeptide-based supramolecular materials are promising for immunotherapy applications because of their biocompatibility and multivalent saccharide display, which enhances lectin-saccharide interactions. This review highlights recent advances in the molecular design of synthetic glycopeptide-based supramolecular materials and their use as immunomodulatory agents. |
| doi_str_mv | 10.1039/d4ob01116c |
| format | Article |
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| ispartof | Organic & biomolecular chemistry, 2024-09, Vol.22 (36), p.7287-7306 |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Animals Aqueous environments Biocompatibility Carbohydrates Displays Glycopeptides Glycopeptides - chemical synthesis Glycopeptides - chemistry Humans Immunomodulation Immunotherapy Macromolecular Substances - chemical synthesis Macromolecular Substances - chemistry Macromolecular Substances - pharmacology Nanoparticles Saccharides Self-assembly Water - chemistry |
| title | Supramolecular materials constructed from synthetic glycopeptides via aqueous self-assembly and their bioapplications in immunotherapy |
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