Design, synthesis, in silico , and in vitro evaluation of pyrrol-2-yl-phenyl allylidene hydrazine carboximidamide derivatives as AChE/BACE 1 dual inhibitors

Alzheimer's disease (AD) manifests as a progressive decline in cognitive function and mental behavior. Targeting two crucial enzymes associated with AD, acetylcholinesterase (AChE) and BACE 1 (Beta-site APP Cleaving Enzyme), in combination, holds promise for therapeutic breakthroughs. In this s...

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Veröffentlicht in:	RSC advances 2024-08, Vol.14 (37), p.26703-26722
Hauptverfasser:	Sharma, Amit, Rudrawar, Santosh, Sharma, Ankita, Bharate, Sandip B, Jadhav, Hemant R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Hydrazines Pharmacology Synthesis
Online-Zugang:	Volltext
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