In vitro assessment of nanomedicines' propensity to cause palmar-plantar erythrodysesthesia: A Doxil vs. doxorubicin case study

Palmar-plantar erythrodysesthesia (PPE), also known as hand and foot syndrome, is a condition characterized by inflammation-mediated damage to the skin on the palms and soles of the hands and feet. PPE limits the successful therapeutic applications of anticancer drugs. However, identifying this toxi...

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Veröffentlicht in:	Nanomedicine 2024-11, Vol.62, p.102780, Article 102780
Hauptverfasser:	Cedrone, Edward, Ishaq, Abbas, Grabarnik, Emma, Edmondson, Elijah, Skoczen, Sarah, Neun, Barry W., Freer, Matthew, Shuttleworth, Siannah, Sviland, Lisbet, Dickinson, Anne, Dobrovolskaia, Marina A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - adverse effects Cytokines Doxorubicin - adverse effects Doxorubicin - analogs & derivatives Hand and foot syndrome Hand-Foot Syndrome - etiology Humans Inflammation Nanomedicine Palmar-plantar erythrodysesthesia PBMC Polyethylene Glycols - adverse effects Polyethylene Glycols - chemistry Skin Skin - drug effects Skin - pathology Skin explant assay Skin lesion
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