Identification of three novel P450 enzymes involved in the oxidative modification of a newly discovered fusicoccane diterpene

[Display omitted] •Genome mining of three gene clusters results in four new fusicoccane diterpenoids.•C5 Oxidation of the fusicoccane skeleton causes broadening NMR signals, which was resolved by variable-temperature NMR.•MgP450 is the first enzyme for hydroxylation of the C19 methyl group of the fu...

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Veröffentlicht in:	Bioorganic chemistry 2024-11, Vol.152, p.107726, Article 107726
Hauptverfasser:	Dong, Lu, Liu, Jing-Yuan, Wang, Gao-Qian, Luo, Pan, Huang, Jia-Hua, Lv, Jian-Ming, Chen, Guo-Dong, Cheng, Wei-Bin, Tian, Jun-Zhang, Lin, Fu-Long, Hu, Dan, Gao, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	CYP450 monooxygenase Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Diterpenes - chemistry Diterpenes - metabolism Fusicoccane-type diterpenoids Genome mining Heterologous expression Molecular Structure Oxidation-Reduction Terpene cyclase
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