Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial
To evaluate the effectiveness of weekly vitamin D supplementation in reducing the number of acute respiratory infections (ARI) in preschool children. Randomized, double-blind, placebo-controlled trial in 303 children aged 1.5-3.5 years from 2014 to 2105 in 3 Chilean cities at different latitudes: Sa...
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| Veröffentlicht in: | The Journal of pediatrics 2024-12, Vol.275, p.114249, Article 114249 |
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| creator | Reyes, María Loreto Vizcaya, Cecilia Le Roy, Catalina Loureiro, Carolina Brinkmann, Karin Arancibia, Mónica Campos, Laura Iturriaga, Carolina Pérez-Mateluna, Guillermo Rojas-McKenzie, Maite Domínguez, Gonzalo Camargo, Carlos A. Borzutzky, Arturo |
| description | To evaluate the effectiveness of weekly vitamin D supplementation in reducing the number of acute respiratory infections (ARI) in preschool children.
Randomized, double-blind, placebo-controlled trial in 303 children aged 1.5-3.5 years from 2014 to 2105 in 3 Chilean cities at different latitudes: Santiago (33°S, n = 101), Talcahuano (37°S, n = 103), and Punta Arenas (53°S, n = 99). Participants were allocated (1:1:1) to receive placebo, cholecalciferol (vitamin D3 (VD3)) 5600 IU/week (low-dose), or 11 200 IU/week (high-dose) for 6 months. Primary outcome was parent-reported number of ARI; secondary outcomes included number of ARI hospitalizations, change of serum 25-hydroxyvitamin D (25(OH)D) and LL-37/cathelicidin levels, and adverse events.
The mean age of participants was 26 ± 6 months; 45% were female. Baseline 25(OH)D was 24.9 ± 6.1 ng/ml, with 23% having 25(OH)D |
| doi_str_mv | 10.1016/j.jpeds.2024.114249 |
| format | Article |
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Randomized, double-blind, placebo-controlled trial in 303 children aged 1.5-3.5 years from 2014 to 2105 in 3 Chilean cities at different latitudes: Santiago (33°S, n = 101), Talcahuano (37°S, n = 103), and Punta Arenas (53°S, n = 99). Participants were allocated (1:1:1) to receive placebo, cholecalciferol (vitamin D3 (VD3)) 5600 IU/week (low-dose), or 11 200 IU/week (high-dose) for 6 months. Primary outcome was parent-reported number of ARI; secondary outcomes included number of ARI hospitalizations, change of serum 25-hydroxyvitamin D (25(OH)D) and LL-37/cathelicidin levels, and adverse events.
The mean age of participants was 26 ± 6 months; 45% were female. Baseline 25(OH)D was 24.9 ± 6.1 ng/ml, with 23% having 25(OH)D <20 ng/ml. No significant baseline clinical or laboratory differences were observed among groups. Overall, 64% (n = 194) completed study participation, without baseline differences between subjects lost to follow-up vs those completing participation or differences in completion rates across groups. After 6 months, a dose-dependent increase in serum 25(OH)D was observed from the VD3 intervention (P < .001), with a higher proportion of subjects ending the trial with 25(OH)D <20 ng/ml in the placebo group (30.8%) vs the low-dose (7.4%) and high-dose groups (5.1%). However, no group differences were observed in number of ARI (P = .85), ARI hospitalizations (P = .20), LL-37/cathelicidin change (P = .30), or adverse events (P = .41).
While weekly VD3 supplementation, in doses equivalent to 800 IU and 1600 IU daily, was associated with improved 25(OH)D levels in preschoolers, we did not find a reduced number of ARI in this sample.</description><identifier>ISSN: 0022-3476</identifier><identifier>ISSN: 1097-6833</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/j.jpeds.2024.114249</identifier><identifier>PMID: 39181322</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; acute respiratory infection ; cathelicidin ; Child, Preschool ; children ; Chile ; Cholecalciferol - administration & dosage ; Cholecalciferol - therapeutic use ; Dietary Supplements ; Double-Blind Method ; Female ; Humans ; Infant ; Male ; Respiratory Tract Infections - prevention & control ; vitamin D ; Vitamin D - administration & dosage ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; vitamin D deficiency ; Vitamin D Deficiency - drug therapy ; Vitamins - administration & dosage</subject><ispartof>The Journal of pediatrics, 2024-12, Vol.275, p.114249, Article 114249</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c239t-d8df7b664b06978d748a482c18a1efd005ddab0ca40aef9244e0ddc5544342883</cites><orcidid>0000-0002-7904-262X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpeds.2024.114249$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39181322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reyes, María Loreto</creatorcontrib><creatorcontrib>Vizcaya, Cecilia</creatorcontrib><creatorcontrib>Le Roy, Catalina</creatorcontrib><creatorcontrib>Loureiro, Carolina</creatorcontrib><creatorcontrib>Brinkmann, Karin</creatorcontrib><creatorcontrib>Arancibia, Mónica</creatorcontrib><creatorcontrib>Campos, Laura</creatorcontrib><creatorcontrib>Iturriaga, Carolina</creatorcontrib><creatorcontrib>Pérez-Mateluna, Guillermo</creatorcontrib><creatorcontrib>Rojas-McKenzie, Maite</creatorcontrib><creatorcontrib>Domínguez, Gonzalo</creatorcontrib><creatorcontrib>Camargo, Carlos A.</creatorcontrib><creatorcontrib>Borzutzky, Arturo</creatorcontrib><title>Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>To evaluate the effectiveness of weekly vitamin D supplementation in reducing the number of acute respiratory infections (ARI) in preschool children.
Randomized, double-blind, placebo-controlled trial in 303 children aged 1.5-3.5 years from 2014 to 2105 in 3 Chilean cities at different latitudes: Santiago (33°S, n = 101), Talcahuano (37°S, n = 103), and Punta Arenas (53°S, n = 99). Participants were allocated (1:1:1) to receive placebo, cholecalciferol (vitamin D3 (VD3)) 5600 IU/week (low-dose), or 11 200 IU/week (high-dose) for 6 months. Primary outcome was parent-reported number of ARI; secondary outcomes included number of ARI hospitalizations, change of serum 25-hydroxyvitamin D (25(OH)D) and LL-37/cathelicidin levels, and adverse events.
The mean age of participants was 26 ± 6 months; 45% were female. Baseline 25(OH)D was 24.9 ± 6.1 ng/ml, with 23% having 25(OH)D <20 ng/ml. No significant baseline clinical or laboratory differences were observed among groups. Overall, 64% (n = 194) completed study participation, without baseline differences between subjects lost to follow-up vs those completing participation or differences in completion rates across groups. After 6 months, a dose-dependent increase in serum 25(OH)D was observed from the VD3 intervention (P < .001), with a higher proportion of subjects ending the trial with 25(OH)D <20 ng/ml in the placebo group (30.8%) vs the low-dose (7.4%) and high-dose groups (5.1%). However, no group differences were observed in number of ARI (P = .85), ARI hospitalizations (P = .20), LL-37/cathelicidin change (P = .30), or adverse events (P = .41).
While weekly VD3 supplementation, in doses equivalent to 800 IU and 1600 IU daily, was associated with improved 25(OH)D levels in preschoolers, we did not find a reduced number of ARI in this sample.</description><subject>Acute Disease</subject><subject>acute respiratory infection</subject><subject>cathelicidin</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Chile</subject><subject>Cholecalciferol - administration & dosage</subject><subject>Cholecalciferol - therapeutic use</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>vitamin D</subject><subject>Vitamin D - administration & dosage</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>vitamin D deficiency</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamins - administration & dosage</subject><issn>0022-3476</issn><issn>1097-6833</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd2O0zAQhS0EYsvCEyAhX3KTMv5JmiBxUXX5WakSaFlAXFmuPQGXxM7azkrlKXhkXLpwydXMSN-Z0ZxDyFMGSwasebFf7ie0acmByyVjksvuHlkw6FZV0wpxnywAOK-EXDVn5FFKewDoJMBDciY61jLB-YL8-oL4YzjQzy7r0Xl6QT_O0zTgiD7r7IKnOdAPEW_LTNdmzkivME0u6hzigV76Hs0RS7SIv4bZf6Ob726wET3VmV64vsd41G7LtjxbTC_pml5pb8PofqKlm-BzDMNQ2uvo9PCYPOj1kPDJXT0nn968vt68q7bv315u1tvKcNHlyra2X-2aRu6g6VatXclWy5Yb1mqGvQWordU7MFqCxr7jUiJYa-paSiF524pz8vy0d4rhZsaU1eiSwWHQHsOclCg-MtlBXRdUnFATQ0oRezVFN-p4UAzUMQq1V3-iUMco1CmKonp2d2DejWj_af56X4BXJwDLm7cOo0rGoTdoXSymKhvcfw_8BkfqnWY</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Reyes, María Loreto</creator><creator>Vizcaya, Cecilia</creator><creator>Le Roy, Catalina</creator><creator>Loureiro, Carolina</creator><creator>Brinkmann, Karin</creator><creator>Arancibia, Mónica</creator><creator>Campos, Laura</creator><creator>Iturriaga, Carolina</creator><creator>Pérez-Mateluna, Guillermo</creator><creator>Rojas-McKenzie, Maite</creator><creator>Domínguez, Gonzalo</creator><creator>Camargo, Carlos A.</creator><creator>Borzutzky, Arturo</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7904-262X</orcidid></search><sort><creationdate>202412</creationdate><title>Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial</title><author>Reyes, María Loreto ; 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Randomized, double-blind, placebo-controlled trial in 303 children aged 1.5-3.5 years from 2014 to 2105 in 3 Chilean cities at different latitudes: Santiago (33°S, n = 101), Talcahuano (37°S, n = 103), and Punta Arenas (53°S, n = 99). Participants were allocated (1:1:1) to receive placebo, cholecalciferol (vitamin D3 (VD3)) 5600 IU/week (low-dose), or 11 200 IU/week (high-dose) for 6 months. Primary outcome was parent-reported number of ARI; secondary outcomes included number of ARI hospitalizations, change of serum 25-hydroxyvitamin D (25(OH)D) and LL-37/cathelicidin levels, and adverse events.
The mean age of participants was 26 ± 6 months; 45% were female. Baseline 25(OH)D was 24.9 ± 6.1 ng/ml, with 23% having 25(OH)D <20 ng/ml. No significant baseline clinical or laboratory differences were observed among groups. Overall, 64% (n = 194) completed study participation, without baseline differences between subjects lost to follow-up vs those completing participation or differences in completion rates across groups. After 6 months, a dose-dependent increase in serum 25(OH)D was observed from the VD3 intervention (P < .001), with a higher proportion of subjects ending the trial with 25(OH)D <20 ng/ml in the placebo group (30.8%) vs the low-dose (7.4%) and high-dose groups (5.1%). However, no group differences were observed in number of ARI (P = .85), ARI hospitalizations (P = .20), LL-37/cathelicidin change (P = .30), or adverse events (P = .41).
While weekly VD3 supplementation, in doses equivalent to 800 IU and 1600 IU daily, was associated with improved 25(OH)D levels in preschoolers, we did not find a reduced number of ARI in this sample.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39181322</pmid><doi>10.1016/j.jpeds.2024.114249</doi><orcidid>https://orcid.org/0000-0002-7904-262X</orcidid></addata></record> |
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| subjects | Acute Disease acute respiratory infection cathelicidin Child, Preschool children Chile Cholecalciferol - administration & dosage Cholecalciferol - therapeutic use Dietary Supplements Double-Blind Method Female Humans Infant Male Respiratory Tract Infections - prevention & control vitamin D Vitamin D - administration & dosage Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency Vitamin D Deficiency - drug therapy Vitamins - administration & dosage |
| title | Weekly Vitamin D Supplementation to Prevent Acute Respiratory Infections in Young Children at Different Latitudes: A Randomized Controlled Trial |
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