Deep serum lipidomics identifies evaluative and predictive biomarkers for individualized glycemic responses following low-energy diet-induced weight loss: a PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) substudy

Weight loss through lifestyle interventions, notably low-energy diets, offers glycemic benefits in populations with overweight-associated prediabetes. However, >50% of these individuals fail to achieve normoglycemia after weight loss. Circulating lipids hold potential for evaluating dietary impac...

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Veröffentlicht in:	The American journal of clinical nutrition 2024-10, Vol.120 (4), p.864-878
Hauptverfasser:	Jiang, Yingxin Celia, Lai, Kaitao, Muirhead, Roslyn Patricia, Chung, Long Hoa, Huang, Yu, James, Elizaveta, Liu, Xin Tracy, Wu, Julian, Atkinson, Fiona S, Yan, Shuang, Fogelholm, Mikael, Raben, Anne, Don, Anthony Simon, Sun, Jing, Brand-Miller, Jennie Cecile, Qi, Yanfei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers Biomarkers - blood Blood Glucose - analysis Blood Glucose - metabolism Body weight Caloric Restriction Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diet Diglycerides Europe Fatty acids Female Health risks Hemoglobin Homeostasis Humans Insulin Insulin resistance Intervention Lecithin Life Style Lifestyles Lipidomics Lipids Lipids - blood low-energy diet Machine learning Male Middle Aged Nutrient deficiency Organic acids Overweight Overweight - blood Overweight - diet therapy Overweight - therapy Parameters Phosphatidylcholine Phosphatidylethanolamine Population studies Population-based studies prediabetes Prediabetic State - blood Prediabetic State - diet therapy Prediabetic State - therapy PREVIEW study Serum lipids Sphingolipids Triglycerides Weight Loss
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