Catatonia in Dementia: A Systematic Review of Case Reports and Case Series

•What is the primary question addressed by this study?What are the clinical features of catatonia in patients with dementia?•What is the main finding of this study?Catatonia in dementia does not have a different syndromic presentation. However, the diagnosis of dementia leads to varying preferences regarding the choice of symptomatic therapy and seems to be a predictor of a poorer therapeutic response.•What is the meaning of the finding?Actively treating catatonia, particularly in patients with dementia, addressing the characteristics of these patients is of paramount importance and may contribute to a better overall prognosis.•TwitterThis systematic review investigates catatonia in the elderly. Dementia influences treatment choices for catatonia and seems to be a predictor of a poorer therapeutic response. Catatonia is a neuropsychiatric syndrome characterized by motor, behavioral, and autonomic abnormalities. It is often underdiagnosed in geriatric patients with dementia despite established diagnostic criteria and treatment options. This systematic review investigates catatonia in the elderly, particularly those with dementia, to examine their clinical presentation, treatment response, and prognosis compared to elderly patients without dementia. We comprehensively searched MEDLINE and EMBASE, including case reports and series on catatonia in elderly patients. Reviewers independently performed data extraction and quality assessments. Statistical significance was set at a p value ≤0.05, and a multivariate logistic regression model was used to analyze differences between patients with and without dementia. Our review included 182 articles with 225 cases. We found no significant differences in the clinical presentation of catatonia between patients with and without dementia, with both groups commonly exhibiting the hypokinetic variant. However, patients with dementia were more frequently treated with NMDA receptor antagonists (OR: 3.27; CI: 1.05–10.11; p = 0.040) and had a lower complete response rate to treatment (OR: 0.37; CI: 0.19–0.75; p = 0.006). Patients with dementia also exhibited fewer acute medical conditions (OR: 0.17; CI: 0.05–0.65; p = 0.009). Catatonia in dementia does not have a different syndromic presentation. However, the diagnosis of dementia leads to varying preferences regarding the choice of symptomatic therapy and seems to be a predictor of a poorer therapeutic response. Actively treating catatonia, particularly in patients with dement