CBX7 promotes choroidal neovascularization by activating the HIF-1α/VEGF pathway in choroidal vascular endothelial cells

Vascular endothelial growth factor (VEGF) signaling is crucial for choroidal neovascularization (CNV), a major pathological feature of neovascular age-related macular degeneration (nAMD). Gene transcription of VEGF is mainly regulated by hypoxia-inducible factor 1-alpha (HIF-1α). The chromobox (CBX)...

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Veröffentlicht in:	Experimental eye research 2024-10, Vol.247, p.110057, Article 110057
Hauptverfasser:	Wang, Qiaoyun, Zhu, Manhui, Li, Wendie, Guo, Yang, Lou, Hui, Zhang, Ji, Xu, Yiqian, Zeng, Bingqing, Wen, Xinghao, Ji, Xiaoyan, Xie, Laiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Movement Cell Proliferation - physiology Cells, Cultured Choroid - blood supply Choroid - metabolism Choroidal neovascularization (CNV) Choroidal Neovascularization - genetics Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Choroidal vascular endothelial cells (CVECs) Chromobox 7 (CBX7) Disease Models, Animal Endothelial Cells - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Gene Expression Regulation Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1-alpha (HIF-1α) Mice Mice, Inbred C57BL Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Real-Time Polymerase Chain Reaction Signal Transduction - physiology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vsascular endothelial growth factor (VEGF)
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