High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis
The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant...
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| Veröffentlicht in: | Journal of neuroimmunology 2024-10, Vol.395, p.578434, Article 578434 |
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| creator | Bilek, Furkan Ercan, Zubeyde Deniz, Gulnihal Ozgul, Sinem Demir, Caner Feyzi |
| description | The study aimed to evaluate the effect of high-intensity intermittent exercise (HIIE) on serum levels of MMP-9 and CHI3L1 in multiple sclerosis. Study group received HIIE twice a week for 12 weeks, while control group received no treatment. In intra-group comparison, study group showed a significant increase in MMP-9 and CHI3L1 levels, while control group showed no significant difference. In intergroup comparison, a significant difference was found only in CHI3L1 levels after treatment. The increase in MMP-9 and CH3L-1 concentrations in study group suggests that these biomarkers may play a role in regulating specific skeletal muscle adaptations due to HIIE.
•High-intensity interval exercise increases serum MMP-9 levels in persons with MS.•High-intensity interval exercise increases serum CHI3L1 levels in persons with MS.•MMP-9 and CHI3L1 may play a role in adaptations in skeletal muscle due to HIEE. |
| doi_str_mv | 10.1016/j.jneuroim.2024.578434 |
| format | Article |
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•High-intensity interval exercise increases serum MMP-9 levels in persons with MS.•High-intensity interval exercise increases serum CHI3L1 levels in persons with MS.•MMP-9 and CHI3L1 may play a role in adaptations in skeletal muscle due to HIEE.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39178495</pmid><doi>10.1016/j.jneuroim.2024.578434</doi></addata></record> |
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| subjects | Adult Biomarker Biomarkers - blood CHI3L1 Chitinase-3-Like Protein 1 - blood Exercise - physiology Exercise Therapy - methods Female High-intensity interval exercise High-Intensity Interval Training - methods Humans Male Matrix Metalloproteinase 9 - blood Middle Aged MMP-9 Multiple sclerosis Multiple Sclerosis - blood Young Adult |
| title | High-intensity intermittent exercise increases serum levels of chitinase 3-like protein-1 and matrix metalloproteinase-9 in persons with multiple sclerosis |
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