Role of volume and inoculum in MIC assessment: a study with meropenem and Klebsiella pneumoniae

Abstract Objectives Pharmacodynamic parameters evaluated under conditions that simulate an infection site volume and microbial load might reveal hidden risks of resistance selection and subsequent treatment failure. The study aimed to investigate the predictive potential of MICs determined at variou...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 2024-10, Vol.79 (10), p.2698-2707
Hauptverfasser:	Alieva, Kamilla N, Golikova, Maria V, Zinner, Stephen H
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Bacterial Load Drug Resistance, Bacterial Humans Klebsiella Infections - drug therapy Klebsiella Infections - microbiology Klebsiella pneumoniae - drug effects Meropenem - pharmacology Microbial Sensitivity Tests Thienamycins - pharmacology
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