A controlled release antibiotic wound protectant gel formulated for use in austere environments

Battlefield wounds are at high risk of infection due to gross contamination and delays in evacuation from forward‐deployed locations. The aim of this study was to formulate an antibiotic wound gel for application by a field medic in austere environments to protect traumatic wounds from infection dur...

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Veröffentlicht in:	Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2024-09, Vol.112 (9), p.e35455-n/a
Hauptverfasser:	Florek, Charles A., Cozzone, Eric, Williams, Dustin L., Armbruster, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology antibiotic Antibiotics Blood Castor oil Cholesterol Controlled release Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology Gels - chemistry Health risks Implantation In vivo methods and tests infection Irrigation local drug delivery Male Military applications oleogel Rats Rats, Sprague-Dawley Resource-Limited Settings Soybean oil Soybeans Sustained release Syringes Temperature requirements Thermal properties Thermodynamic properties Tissues Tobramycin Wound infection wound protectant
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