PEITC Induces DNA Damage and Inhibits DNA Repair‐Associated Proteins in Human Retinoblastoma Cells In Vitro

ABSTRACT Phenethyl isothiocyanate (PEITC), a natural product, exists in biological activities, including anticancer activity in many human cancer cells. No information shows that PEITC affects DNA damage in human retinoblastoma (RB) cells in vitro. In this study, the aim of experiments was to determ...

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Veröffentlicht in:	Environmental toxicology 2024-12, Vol.39 (12), p.5274-5283
Hauptverfasser:	Hsu, Sheng‐Yao, Huang, Yi‐Ping, Hsia, Te‐Chun, Chen, Jaw‐Chyun, Peng, Shu‐Fen, Hsieh, Wen‐Tsong, Chueh, Fu‐Shin, Kuo, Chao‐Lin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor activity Assaying Bioassays Biological activity Catalase Cell Line, Tumor Cell migration Cell number Cell Survival - drug effects Cell viability Cells Comet Assay Comet nuclei Condensates Condensation Cytotoxicity Damage Damage detection Deoxyribonucleic acid DNA DNA damage DNA Damage - drug effects DNA repair DNA Repair - drug effects Fluorescence Glutathione Hsp70 protein Hsp90 protein Humans Isothiocyanates - pharmacology Laser damage Laser microscopy Microscopy Natural products Oxidative stress p53 Protein PEITC Phenethyl isothiocyanate Proteins Retinoblastoma Retinoblastoma - pathology Retinoblastoma protein Staining Toxicity tests Western blotting Y79 human retinoblastoma (RB) cells
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