Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC

High invasive capacity and acquired tyrosine kinase inhibitors (TKI) resistance of kidney renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of patients with advanced KIRC. In the present study, we reported that sine oculis homeobox 1 (SIX1) was upregulated in s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2024-09, Vol.43 (39), p.2951-2969
Hauptverfasser:	Huang, Shiyu, Hu, Juncheng, Hu, Min, Hou, Yanguang, Zhang, Banghua, Liu, Jiachen, Liu, Xiuheng, Chen, Zhiyuan, Wang, Lei
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/31 13/51 14/34 38/77 38/91 42/41 631/67/1059/2326 631/67/322 631/67/589/1588/1351 631/80/84/2027 64/60 692/53/2422 82/58 82/80 82/83 96/47 96/95 Animals Apoptosis Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - metabolism Carcinoma, Renal Cell - pathology Cell Biology Cell Line, Tumor DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - metabolism DNA helicase Drug Resistance, Neoplasm - genetics Focal Adhesion Kinase 1 Focal Adhesions - genetics Focal Adhesions - metabolism Gene Expression Regulation, Neoplastic Gene silencing Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human Genetics Humans Integrin beta1 - genetics Integrin beta1 - metabolism Integrins - genetics Integrins - metabolism Internal Medicine Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kidney Neoplasms - pathology Kinases Medicine Medicine & Public Health Metastases Metastasis Mice Neoplasm Metastasis Nuclear transport Oncology Renal cell carcinoma Signal Transduction SIX gene family Sunitinib - pharmacology Sunitinib - therapeutic use Transcription, Genetic Tyrosine kinase inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!