Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis
Background Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirem...
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| Veröffentlicht in: | Obesity surgery 2024-10, Vol.34 (10), p.3735-3747 |
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| creator | Silva, Adriana Fernandes Bestetti, Alexandre Moraes Kum, Angelo So Taa Nunes, Beanie Conceição Medeiros de Oliveira Veras, Matheus Bernardo, Wanderley Marques de Moura, Eduardo Guimarães Hourneaux |
| description | Background
Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirements of major guidelines and allows significant weight loss with few adverse events. This systematic review and meta-analysis aims to demonstrate the efficacy and safety profile of this new device for weight loss.
Methods
We conducted a search from 2016 to 2024 to assess the efficacy of the swallowable intragastric balloon for weight loss, including improvements in metabolic profiles and anthropometric measurements. Additionally, we evaluated potential adverse events related to the device to demonstrate its safety.
Results
Eleven observational studies totalling 2107 patients were included, showing a reduction of 4.75 in BMI (95% CI: -5.02; -4.47), a mean total weight loss of 12.47% (95% CI: -13.77; -11.17), a mean excess weight loss of 48.04% (95% CI: -50.61; -45.48), and a rate of serious adverse events of 0.90%. An improvement in the metabolic profile was observed for three parameters: HDL, triglycerides, and glycaemia.
Conclusion
The swallowable liquid-filled intragastric balloon is safe and effective for managing weight loss within a four-month follow-up period.
Graphical Abstract |
| doi_str_mv | 10.1007/s11695-024-07453-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3096279940</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3114600587</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-b1ebe90309c82b62ffe9b334696d02f9aabdfd9342fb164c5c713306e6396a1a3</originalsourceid><addsrcrecordid>eNp9kc1u1DAURi1ERaeFF2CBLLFhY7j-iROzG6pSKk1ViQGxjJzkeiZVEhfb6WiegZfG7RSQWHRlyT7fd311CHnN4T0HKD9EzrUpGAjFoFSFZMUzsuAlVAyUqJ6TBRgNrDJCHpOTGG8ABNdCvCDH0vBSVVosyK9z57BN_R1OGCO1U0fX1mHaU-9o2iJdDsMcej_R9c4Og9_ZZkB6OaVgNzam0Lf00_19BpwPdL31IbGEYaQ_sN9sE135GD_SJV3vY8LRphz4inc97h5mXWGyzE522Mc-viRHzg4RXz2ep-T75_NvZ1_Y6vri8my5Yq0odGINxwYNSDBtJRot8gKmkVJpozsQzljbdK4zUgnXcK3aoi25lKBRS6Mtt_KUvDv03gb_c8aY6rGPLQ6DndDPsc7NWpTGKMjo2__QGz-H_N9Mca40QFGVmRIHqg1524Cuvg39aMO-5lDfq6oPquqsqn5QVRc59Oaxem5G7P5G_rjJgDwAMT9NGwz_Zj9R-xs_jZ_t</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3114600587</pqid></control><display><type>article</type><title>Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis</title><source>SpringerNature Journals</source><creator>Silva, Adriana Fernandes ; Bestetti, Alexandre Moraes ; Kum, Angelo So Taa ; Nunes, Beanie Conceição Medeiros ; de Oliveira Veras, Matheus ; Bernardo, Wanderley Marques ; de Moura, Eduardo Guimarães Hourneaux</creator><creatorcontrib>Silva, Adriana Fernandes ; Bestetti, Alexandre Moraes ; Kum, Angelo So Taa ; Nunes, Beanie Conceição Medeiros ; de Oliveira Veras, Matheus ; Bernardo, Wanderley Marques ; de Moura, Eduardo Guimarães Hourneaux</creatorcontrib><description>Background
Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirements of major guidelines and allows significant weight loss with few adverse events. This systematic review and meta-analysis aims to demonstrate the efficacy and safety profile of this new device for weight loss.
Methods
We conducted a search from 2016 to 2024 to assess the efficacy of the swallowable intragastric balloon for weight loss, including improvements in metabolic profiles and anthropometric measurements. Additionally, we evaluated potential adverse events related to the device to demonstrate its safety.
Results
Eleven observational studies totalling 2107 patients were included, showing a reduction of 4.75 in BMI (95% CI: -5.02; -4.47), a mean total weight loss of 12.47% (95% CI: -13.77; -11.17), a mean excess weight loss of 48.04% (95% CI: -50.61; -45.48), and a rate of serious adverse events of 0.90%. An improvement in the metabolic profile was observed for three parameters: HDL, triglycerides, and glycaemia.
Conclusion
The swallowable liquid-filled intragastric balloon is safe and effective for managing weight loss within a four-month follow-up period.
Graphical Abstract</description><identifier>ISSN: 0960-8923</identifier><identifier>ISSN: 1708-0428</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-024-07453-5</identifier><identifier>PMID: 39174862</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Medicine ; Medicine & Public Health ; Metabolism ; Original Contributions ; Surgery ; Systematic review</subject><ispartof>Obesity surgery, 2024-10, Vol.34 (10), p.3735-3747</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-b1ebe90309c82b62ffe9b334696d02f9aabdfd9342fb164c5c713306e6396a1a3</cites><orcidid>0000-0001-6182-1644 ; 0000-0002-8023-3722 ; 0000-0003-2626-8235 ; 0009-0001-4835-9296 ; 0000-0002-5358-2169 ; 0000-0002-8597-5207 ; 0000-0001-9881-9855</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11695-024-07453-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11695-024-07453-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39174862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Adriana Fernandes</creatorcontrib><creatorcontrib>Bestetti, Alexandre Moraes</creatorcontrib><creatorcontrib>Kum, Angelo So Taa</creatorcontrib><creatorcontrib>Nunes, Beanie Conceição Medeiros</creatorcontrib><creatorcontrib>de Oliveira Veras, Matheus</creatorcontrib><creatorcontrib>Bernardo, Wanderley Marques</creatorcontrib><creatorcontrib>de Moura, Eduardo Guimarães Hourneaux</creatorcontrib><title>Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirements of major guidelines and allows significant weight loss with few adverse events. This systematic review and meta-analysis aims to demonstrate the efficacy and safety profile of this new device for weight loss.
Methods
We conducted a search from 2016 to 2024 to assess the efficacy of the swallowable intragastric balloon for weight loss, including improvements in metabolic profiles and anthropometric measurements. Additionally, we evaluated potential adverse events related to the device to demonstrate its safety.
Results
Eleven observational studies totalling 2107 patients were included, showing a reduction of 4.75 in BMI (95% CI: -5.02; -4.47), a mean total weight loss of 12.47% (95% CI: -13.77; -11.17), a mean excess weight loss of 48.04% (95% CI: -50.61; -45.48), and a rate of serious adverse events of 0.90%. An improvement in the metabolic profile was observed for three parameters: HDL, triglycerides, and glycaemia.
Conclusion
The swallowable liquid-filled intragastric balloon is safe and effective for managing weight loss within a four-month follow-up period.
Graphical Abstract</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolism</subject><subject>Original Contributions</subject><subject>Surgery</subject><subject>Systematic review</subject><issn>0960-8923</issn><issn>1708-0428</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAURi1ERaeFF2CBLLFhY7j-iROzG6pSKk1ViQGxjJzkeiZVEhfb6WiegZfG7RSQWHRlyT7fd311CHnN4T0HKD9EzrUpGAjFoFSFZMUzsuAlVAyUqJ6TBRgNrDJCHpOTGG8ABNdCvCDH0vBSVVosyK9z57BN_R1OGCO1U0fX1mHaU-9o2iJdDsMcej_R9c4Og9_ZZkB6OaVgNzam0Lf00_19BpwPdL31IbGEYaQ_sN9sE135GD_SJV3vY8LRphz4inc97h5mXWGyzE522Mc-viRHzg4RXz2ep-T75_NvZ1_Y6vri8my5Yq0odGINxwYNSDBtJRot8gKmkVJpozsQzljbdK4zUgnXcK3aoi25lKBRS6Mtt_KUvDv03gb_c8aY6rGPLQ6DndDPsc7NWpTGKMjo2__QGz-H_N9Mca40QFGVmRIHqg1524Cuvg39aMO-5lDfq6oPquqsqn5QVRc59Oaxem5G7P5G_rjJgDwAMT9NGwz_Zj9R-xs_jZ_t</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Silva, Adriana Fernandes</creator><creator>Bestetti, Alexandre Moraes</creator><creator>Kum, Angelo So Taa</creator><creator>Nunes, Beanie Conceição Medeiros</creator><creator>de Oliveira Veras, Matheus</creator><creator>Bernardo, Wanderley Marques</creator><creator>de Moura, Eduardo Guimarães Hourneaux</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6182-1644</orcidid><orcidid>https://orcid.org/0000-0002-8023-3722</orcidid><orcidid>https://orcid.org/0000-0003-2626-8235</orcidid><orcidid>https://orcid.org/0009-0001-4835-9296</orcidid><orcidid>https://orcid.org/0000-0002-5358-2169</orcidid><orcidid>https://orcid.org/0000-0002-8597-5207</orcidid><orcidid>https://orcid.org/0000-0001-9881-9855</orcidid></search><sort><creationdate>20241001</creationdate><title>Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis</title><author>Silva, Adriana Fernandes ; Bestetti, Alexandre Moraes ; Kum, Angelo So Taa ; Nunes, Beanie Conceição Medeiros ; de Oliveira Veras, Matheus ; Bernardo, Wanderley Marques ; de Moura, Eduardo Guimarães Hourneaux</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-b1ebe90309c82b62ffe9b334696d02f9aabdfd9342fb164c5c713306e6396a1a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolism</topic><topic>Original Contributions</topic><topic>Surgery</topic><topic>Systematic review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Adriana Fernandes</creatorcontrib><creatorcontrib>Bestetti, Alexandre Moraes</creatorcontrib><creatorcontrib>Kum, Angelo So Taa</creatorcontrib><creatorcontrib>Nunes, Beanie Conceição Medeiros</creatorcontrib><creatorcontrib>de Oliveira Veras, Matheus</creatorcontrib><creatorcontrib>Bernardo, Wanderley Marques</creatorcontrib><creatorcontrib>de Moura, Eduardo Guimarães Hourneaux</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Adriana Fernandes</au><au>Bestetti, Alexandre Moraes</au><au>Kum, Angelo So Taa</au><au>Nunes, Beanie Conceição Medeiros</au><au>de Oliveira Veras, Matheus</au><au>Bernardo, Wanderley Marques</au><au>de Moura, Eduardo Guimarães Hourneaux</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>34</volume><issue>10</issue><spage>3735</spage><epage>3747</epage><pages>3735-3747</pages><issn>0960-8923</issn><issn>1708-0428</issn><eissn>1708-0428</eissn><abstract>Background
Obesity poses a severe health problem worldwide, with an estimated impact on 17.5% of the adult population by 2035. Among the endoscopic applications for treating this comorbidity, intragastric balloons are the most widely used. The new liquid-filled swallowable balloon meets the requirements of major guidelines and allows significant weight loss with few adverse events. This systematic review and meta-analysis aims to demonstrate the efficacy and safety profile of this new device for weight loss.
Methods
We conducted a search from 2016 to 2024 to assess the efficacy of the swallowable intragastric balloon for weight loss, including improvements in metabolic profiles and anthropometric measurements. Additionally, we evaluated potential adverse events related to the device to demonstrate its safety.
Results
Eleven observational studies totalling 2107 patients were included, showing a reduction of 4.75 in BMI (95% CI: -5.02; -4.47), a mean total weight loss of 12.47% (95% CI: -13.77; -11.17), a mean excess weight loss of 48.04% (95% CI: -50.61; -45.48), and a rate of serious adverse events of 0.90%. An improvement in the metabolic profile was observed for three parameters: HDL, triglycerides, and glycaemia.
Conclusion
The swallowable liquid-filled intragastric balloon is safe and effective for managing weight loss within a four-month follow-up period.
Graphical Abstract</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39174862</pmid><doi>10.1007/s11695-024-07453-5</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-6182-1644</orcidid><orcidid>https://orcid.org/0000-0002-8023-3722</orcidid><orcidid>https://orcid.org/0000-0003-2626-8235</orcidid><orcidid>https://orcid.org/0009-0001-4835-9296</orcidid><orcidid>https://orcid.org/0000-0002-5358-2169</orcidid><orcidid>https://orcid.org/0000-0002-8597-5207</orcidid><orcidid>https://orcid.org/0000-0001-9881-9855</orcidid></addata></record> |
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| ispartof | Obesity surgery, 2024-10, Vol.34 (10), p.3735-3747 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Medicine Medicine & Public Health Metabolism Original Contributions Surgery Systematic review |
| title | Effectiveness and Safety of the Allurion Swallowable Intragastric Balloon for Short-term Weight Loss: A Systematic Review and Meta-analysis |
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