Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer
•The optimum extent of neck lymphadenectomy on disease prognosis is unclear, and studies on this topic are sparse in pediatric PTC, despite the need for such data to help guide practice. Under the scenario of the high prevalence of N1b status observed in pediatric PTC, the current study was designed...
Gespeichert in:
| Veröffentlicht in: | Oral oncology 2024-11, Vol.158, p.106984, Article 106984 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 106984 |
| container_title | Oral oncology |
| container_volume | 158 |
| creator | Wei, Yizhuo Xiao, Liu Liu, Lina Shi, Lei Wang, Yu Liu, Bin |
| description | •The optimum extent of neck lymphadenectomy on disease prognosis is unclear, and studies on this topic are sparse in pediatric PTC, despite the need for such data to help guide practice. Under the scenario of the high prevalence of N1b status observed in pediatric PTC, the current study was designed to investigate the association between LN yield and oncological outcomes in pediatric patients with N1b PTC.•To our knowledge, this was the first study to assess the implications of LN yield on oncological outcomes in pediatric patients with N1b PTC. Our study suggested that LN yield was an independent predictor of overall outcomes. At a cutoff value of 42 LNs, a less-extensive lymphadenectomy ( |
| doi_str_mv | 10.1016/j.oraloncology.2024.106984 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3096279149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1368837524003026</els_id><sourcerecordid>3096279149</sourcerecordid><originalsourceid>FETCH-LOGICAL-c253t-d8e10a18b24ea62c89d60f3f1abab733661293d42b1c53d8acd1270ba8b62da3</originalsourceid><addsrcrecordid>eNqNkMtOxCAUQInR-P4FQ1y56cijpeDO-E6Mupg9oUAdJm2pwGj69zKZ0bh0dW8u5z44AJxjNMMIs8vlzAfV-UH7zr9PM4JImR-Y4OUOOMS8FgWqBN3NOWW84LSuDsBRjEuEUIUrtA8OqMA1LSt6CPRb8O-Dj8lp6Pqxc1ol54cIfQu7qR8XcPDGwsnZzkA3wNEap1LI9JhBO6QIv1xawBfc5Mrouk6FCabFFLwzUKtB23AC9lrVRXu6jcdgfn83v3ksnl8fnm6unwtNKpoKwy1GCvOGlFYxorkwDLW0xapRTU0pY5gIakrSYF1Rw5U2mNSoUbxhxCh6DC42Y8fgP1Y2Jtm7qG2-aLB-FSVFgpFa4FJk9GqD6uBjDLaVY3B9vlxiJNeO5VL-dSzXjuXGcW4-2-5ZNb01v60_UjNwuwFs_uyns0FGnVXprC5YnaTx7j97vgHo6ZZ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3096279149</pqid></control><display><type>article</type><title>Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wei, Yizhuo ; Xiao, Liu ; Liu, Lina ; Shi, Lei ; Wang, Yu ; Liu, Bin</creator><creatorcontrib>Wei, Yizhuo ; Xiao, Liu ; Liu, Lina ; Shi, Lei ; Wang, Yu ; Liu, Bin</creatorcontrib><description>•The optimum extent of neck lymphadenectomy on disease prognosis is unclear, and studies on this topic are sparse in pediatric PTC, despite the need for such data to help guide practice. Under the scenario of the high prevalence of N1b status observed in pediatric PTC, the current study was designed to investigate the association between LN yield and oncological outcomes in pediatric patients with N1b PTC.•To our knowledge, this was the first study to assess the implications of LN yield on oncological outcomes in pediatric patients with N1b PTC. Our study suggested that LN yield was an independent predictor of overall outcomes. At a cutoff value of 42 LNs, a less-extensive lymphadenectomy (<42 LNs) was associated with increased risk of persistent diseases (hazard ratio, 2.4).
To investigate whether lymph node (LN) yield influences clinical outcomes for pediatric patients with laterocervical lymph node metastasis (N1b) from papillary thyroid cancer (PTC).
Conducted from January 1, 2008, to December 31, 2022, this was a cohort study of pediatric patients (aged ≤ 18 years) with N1b PTC who underwent total thyroidectomy and therapeutic LN dissection in the central and lateral compartments at 3 hospitals in southwest China in 2008–2021, with follow-up until 2022. Patients with distant metastasis were excluded. Univariate and multivariate Cox proportional hazards regression analyses were used to identify factors associated with persistent/recurrent diseases.
A total of 102 pediatric patients (median [range] age, 16 [6–18] years) were analyzed: 36 patients (35 %) with T1; 27 patients (26 %), T2; 18 patients (18 %), T3; and 21 patients (21 %), T4. During a median follow-up of 50 months (range, 12–154 months), persistent diseases occurred in 40 (39 %) patients. Receiver operating characteristic analysis identified LN yield cut‐off (<42 LNs) to predict persistent diseases. Multivariate analysis revealed that a less-extensive lymphadenectomy (<42 LNs) was an independent risk factor for persistent diseases (hazard ratio, 2.4; 95 % confidence intervals, 1.09–5.29; P=.029).
Our study highlights that a higher LN yield may favorably influence prognosis in pediatric patients with N1b PTC.</description><identifier>ISSN: 1368-8375</identifier><identifier>ISSN: 1879-0593</identifier><identifier>EISSN: 1879-0593</identifier><identifier>DOI: 10.1016/j.oraloncology.2024.106984</identifier><identifier>PMID: 39173453</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adolescent ; Child ; Clinical outcomes ; Female ; Humans ; Lymph Node Excision ; Lymph node yield ; Lymph Nodes - pathology ; Lymphatic Metastasis ; Male ; N1b ; Neck dissection ; Pediatric papillary thyroid cancer ; Prognosis ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy</subject><ispartof>Oral oncology, 2024-11, Vol.158, p.106984, Article 106984</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c253t-d8e10a18b24ea62c89d60f3f1abab733661293d42b1c53d8acd1270ba8b62da3</cites><orcidid>0000-0002-0636-9680</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.oraloncology.2024.106984$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39173453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Yizhuo</creatorcontrib><creatorcontrib>Xiao, Liu</creatorcontrib><creatorcontrib>Liu, Lina</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><title>Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer</title><title>Oral oncology</title><addtitle>Oral Oncol</addtitle><description>•The optimum extent of neck lymphadenectomy on disease prognosis is unclear, and studies on this topic are sparse in pediatric PTC, despite the need for such data to help guide practice. Under the scenario of the high prevalence of N1b status observed in pediatric PTC, the current study was designed to investigate the association between LN yield and oncological outcomes in pediatric patients with N1b PTC.•To our knowledge, this was the first study to assess the implications of LN yield on oncological outcomes in pediatric patients with N1b PTC. Our study suggested that LN yield was an independent predictor of overall outcomes. At a cutoff value of 42 LNs, a less-extensive lymphadenectomy (<42 LNs) was associated with increased risk of persistent diseases (hazard ratio, 2.4).
To investigate whether lymph node (LN) yield influences clinical outcomes for pediatric patients with laterocervical lymph node metastasis (N1b) from papillary thyroid cancer (PTC).
Conducted from January 1, 2008, to December 31, 2022, this was a cohort study of pediatric patients (aged ≤ 18 years) with N1b PTC who underwent total thyroidectomy and therapeutic LN dissection in the central and lateral compartments at 3 hospitals in southwest China in 2008–2021, with follow-up until 2022. Patients with distant metastasis were excluded. Univariate and multivariate Cox proportional hazards regression analyses were used to identify factors associated with persistent/recurrent diseases.
A total of 102 pediatric patients (median [range] age, 16 [6–18] years) were analyzed: 36 patients (35 %) with T1; 27 patients (26 %), T2; 18 patients (18 %), T3; and 21 patients (21 %), T4. During a median follow-up of 50 months (range, 12–154 months), persistent diseases occurred in 40 (39 %) patients. Receiver operating characteristic analysis identified LN yield cut‐off (<42 LNs) to predict persistent diseases. Multivariate analysis revealed that a less-extensive lymphadenectomy (<42 LNs) was an independent risk factor for persistent diseases (hazard ratio, 2.4; 95 % confidence intervals, 1.09–5.29; P=.029).
Our study highlights that a higher LN yield may favorably influence prognosis in pediatric patients with N1b PTC.</description><subject>Adolescent</subject><subject>Child</subject><subject>Clinical outcomes</subject><subject>Female</subject><subject>Humans</subject><subject>Lymph Node Excision</subject><subject>Lymph node yield</subject><subject>Lymph Nodes - pathology</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>N1b</subject><subject>Neck dissection</subject><subject>Pediatric papillary thyroid cancer</subject><subject>Prognosis</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><issn>1368-8375</issn><issn>1879-0593</issn><issn>1879-0593</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOxCAUQInR-P4FQ1y56cijpeDO-E6Mupg9oUAdJm2pwGj69zKZ0bh0dW8u5z44AJxjNMMIs8vlzAfV-UH7zr9PM4JImR-Y4OUOOMS8FgWqBN3NOWW84LSuDsBRjEuEUIUrtA8OqMA1LSt6CPRb8O-Dj8lp6Pqxc1ol54cIfQu7qR8XcPDGwsnZzkA3wNEap1LI9JhBO6QIv1xawBfc5Mrouk6FCabFFLwzUKtB23AC9lrVRXu6jcdgfn83v3ksnl8fnm6unwtNKpoKwy1GCvOGlFYxorkwDLW0xapRTU0pY5gIakrSYF1Rw5U2mNSoUbxhxCh6DC42Y8fgP1Y2Jtm7qG2-aLB-FSVFgpFa4FJk9GqD6uBjDLaVY3B9vlxiJNeO5VL-dSzXjuXGcW4-2-5ZNb01v60_UjNwuwFs_uyns0FGnVXprC5YnaTx7j97vgHo6ZZ4</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Wei, Yizhuo</creator><creator>Xiao, Liu</creator><creator>Liu, Lina</creator><creator>Shi, Lei</creator><creator>Wang, Yu</creator><creator>Liu, Bin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0636-9680</orcidid></search><sort><creationdate>202411</creationdate><title>Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer</title><author>Wei, Yizhuo ; Xiao, Liu ; Liu, Lina ; Shi, Lei ; Wang, Yu ; Liu, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-d8e10a18b24ea62c89d60f3f1abab733661293d42b1c53d8acd1270ba8b62da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Clinical outcomes</topic><topic>Female</topic><topic>Humans</topic><topic>Lymph Node Excision</topic><topic>Lymph node yield</topic><topic>Lymph Nodes - pathology</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>N1b</topic><topic>Neck dissection</topic><topic>Pediatric papillary thyroid cancer</topic><topic>Prognosis</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Yizhuo</creatorcontrib><creatorcontrib>Xiao, Liu</creatorcontrib><creatorcontrib>Liu, Lina</creatorcontrib><creatorcontrib>Shi, Lei</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Liu, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oral oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Yizhuo</au><au>Xiao, Liu</au><au>Liu, Lina</au><au>Shi, Lei</au><au>Wang, Yu</au><au>Liu, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer</atitle><jtitle>Oral oncology</jtitle><addtitle>Oral Oncol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>158</volume><spage>106984</spage><pages>106984-</pages><artnum>106984</artnum><issn>1368-8375</issn><issn>1879-0593</issn><eissn>1879-0593</eissn><abstract>•The optimum extent of neck lymphadenectomy on disease prognosis is unclear, and studies on this topic are sparse in pediatric PTC, despite the need for such data to help guide practice. Under the scenario of the high prevalence of N1b status observed in pediatric PTC, the current study was designed to investigate the association between LN yield and oncological outcomes in pediatric patients with N1b PTC.•To our knowledge, this was the first study to assess the implications of LN yield on oncological outcomes in pediatric patients with N1b PTC. Our study suggested that LN yield was an independent predictor of overall outcomes. At a cutoff value of 42 LNs, a less-extensive lymphadenectomy (<42 LNs) was associated with increased risk of persistent diseases (hazard ratio, 2.4).
To investigate whether lymph node (LN) yield influences clinical outcomes for pediatric patients with laterocervical lymph node metastasis (N1b) from papillary thyroid cancer (PTC).
Conducted from January 1, 2008, to December 31, 2022, this was a cohort study of pediatric patients (aged ≤ 18 years) with N1b PTC who underwent total thyroidectomy and therapeutic LN dissection in the central and lateral compartments at 3 hospitals in southwest China in 2008–2021, with follow-up until 2022. Patients with distant metastasis were excluded. Univariate and multivariate Cox proportional hazards regression analyses were used to identify factors associated with persistent/recurrent diseases.
A total of 102 pediatric patients (median [range] age, 16 [6–18] years) were analyzed: 36 patients (35 %) with T1; 27 patients (26 %), T2; 18 patients (18 %), T3; and 21 patients (21 %), T4. During a median follow-up of 50 months (range, 12–154 months), persistent diseases occurred in 40 (39 %) patients. Receiver operating characteristic analysis identified LN yield cut‐off (<42 LNs) to predict persistent diseases. Multivariate analysis revealed that a less-extensive lymphadenectomy (<42 LNs) was an independent risk factor for persistent diseases (hazard ratio, 2.4; 95 % confidence intervals, 1.09–5.29; P=.029).
Our study highlights that a higher LN yield may favorably influence prognosis in pediatric patients with N1b PTC.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39173453</pmid><doi>10.1016/j.oraloncology.2024.106984</doi><orcidid>https://orcid.org/0000-0002-0636-9680</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1368-8375 |
| ispartof | Oral oncology, 2024-11, Vol.158, p.106984, Article 106984 |
| issn | 1368-8375 1879-0593 1879-0593 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3096279149 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Child Clinical outcomes Female Humans Lymph Node Excision Lymph node yield Lymph Nodes - pathology Lymphatic Metastasis Male N1b Neck dissection Pediatric papillary thyroid cancer Prognosis Thyroid Cancer, Papillary - pathology Thyroid Cancer, Papillary - surgery Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy |
| title | Prognostic implications of lymph node yield in pediatric patients with N1b papillary thyroid cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T06%3A53%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20implications%20of%20lymph%20node%20yield%20in%20pediatric%20patients%20with%20N1b%20papillary%20thyroid%20cancer&rft.jtitle=Oral%20oncology&rft.au=Wei,%20Yizhuo&rft.date=2024-11&rft.volume=158&rft.spage=106984&rft.pages=106984-&rft.artnum=106984&rft.issn=1368-8375&rft.eissn=1879-0593&rft_id=info:doi/10.1016/j.oraloncology.2024.106984&rft_dat=%3Cproquest_cross%3E3096279149%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3096279149&rft_id=info:pmid/39173453&rft_els_id=S1368837524003026&rfr_iscdi=true |