Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2

While macrophage heterogeneity during metabolic dysfunction-associated steatohepatitis (MASH) has been described, the fate of these macrophages during MASH regression is poorly understood. Comparing macrophage heterogeneity during MASH progression vs regression, we identified specific macrophage sub...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-08, Vol.121 (35), p.e2405746121
Hauptverfasser:	Ganguly, Souradipta, Rosenthal, Sara Brin, Ishizuka, Kei, Troutman, Ty D, Rohm, Theresa V, Khader, Naser, Aleman-Muench, German, Sano, Yasuyo, Archilei, Sebastiano, Soroosh, Pejman, Olefsky, Jerrold M, Feldstein, Ariel E, Kisseleva, Tatiana, Loomba, Rohit, Glass, Christopher K, Brenner, David A, Dhar, Debanjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Collagen Fatty liver Fatty Liver - genetics Fatty Liver - metabolism Fatty Liver - pathology Fibrosis Hepatocytes Heterogeneity Inactivation Kupffer cells Kupffer Cells - metabolism Lipid Metabolism Lipids Liver Liver - metabolism Liver - pathology Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Macrophages Macrophages - metabolism Male Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metabolism Mice Mice, Inbred C57BL Mice, Knockout Monocytes Phagocytosis Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Regression Steatosis Subpopulations
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