KIAA1199/CEMIP knockdown attenuates cardiac remodeling post myocardial infarction by activating TSP4 pathway in mice

Excessive activation of cardiac fibroblasts (CFs) significantly contributes to adverse cardiac remodeling post-myocardial infarction (MI). CEMIP, initially recognized as an enzyme involved in hyaluronic acid (HA) degradation, has also been implicated in the activation of pulmonary fibroblasts. Never...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2024-12, Vol.1870 (8), p.167473, Article 167473
Hauptverfasser:	Zha, Yafang, Luo, Xueyang, Ge, Zhuowang, Zhang, Jiayan, Li, Yanyan, Zhang, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTN4 Animals Cardiac remodeling CEMIP Disease Models, Animal Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gene Knockdown Techniques Humans Hyaluronoglucosaminidase - genetics Hyaluronoglucosaminidase - metabolism Lysosome-mediated degradation Male Mice Mice, Inbred C57BL Myocardial Infarction - genetics Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardium - metabolism Myocardium - pathology Signal Transduction Thrombospondins - genetics Thrombospondins - metabolism TSP4 Ventricular Remodeling - genetics
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