Synthesis and evaluation of isothiazolo4,5-bpyridines as cyclin G-associated kinase (GAK) inhibitors

Isothiazolo[4,3-b]pyridines have been extensively explored as inhibitors of cyclin G-associated kinase (GAK). In order to expand the structure-activity relationship study and to discover other chemotypes that act as GAK inhibitors, the closely related isothiazolo[4,5-b]pyridine scaffold was explored...

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Veröffentlicht in:	Organic & biomolecular chemistry 2024-09, Vol.22 (36), p.7373
Hauptverfasser:	Ivanova, Yulia, Spittaels, Sander, Gao, Ling-Jie, Schols, Dominique, Van Meervelt, Luc, Froeyen, Mathy, Dehaen, Wim, De Jonghe, Steven
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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