The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity
Adequate serum vitamin D levels correlate with a more favorable lipid profile compared to deficient levels. Despite the well-established prevalence of vitamin D deficiency in children with obesity, studies investigating its influence on lipid profiles in this population are scarce. We explored the i...
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| creator | Calcaterra, Valeria Fabiano, Valentina De Silvestri, Annalisa Colombo, Carla Tranfaglia, Valeria Loiodice, Martina Ceruti, Daniele Zuccotti, Gianvincenzo |
| description | Adequate serum vitamin D levels correlate with a more favorable lipid profile compared to deficient levels. Despite the well-established prevalence of vitamin D deficiency in children with obesity, studies investigating its influence on lipid profiles in this population are scarce. We explored the impact of vitamin D status on lipid profiles and markers of atherogenic dyslipidemia in a cohort of children and adolescents with obesity.
A total of 271 Caucasian children and adolescents with overweight/obesity and a control group of 54 pediatric patients with normal weight. All participants underwent outpatient visits for the assessment of clinical parameters and venous blood collection for biochemical analysis such as triglycerides (TG)/HDL-C ratio, LDL-C/HDL-C ratio, atherogenic index of plasma AIP), vitamin D level.
Individuals with obesity displayed severe vitamin D deficiency (25-OH-D ≤10 ng/ml) at a higher frequency compared to those with normal weight (p = 0.03). In patients with overweight/obesity and low 25-OH-D levels show higher values of glycemia (p = 0.001), insulin resistance (HOMA-IR and TRYG p |
| doi_str_mv | 10.1016/j.numecd.2024.07.015 |
| format | Article |
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A total of 271 Caucasian children and adolescents with overweight/obesity and a control group of 54 pediatric patients with normal weight. All participants underwent outpatient visits for the assessment of clinical parameters and venous blood collection for biochemical analysis such as triglycerides (TG)/HDL-C ratio, LDL-C/HDL-C ratio, atherogenic index of plasma AIP), vitamin D level.
Individuals with obesity displayed severe vitamin D deficiency (25-OH-D ≤10 ng/ml) at a higher frequency compared to those with normal weight (p = 0.03). In patients with overweight/obesity and low 25-OH-D levels show higher values of glycemia (p = 0.001), insulin resistance (HOMA-IR and TRYG p < 0.001), TG (p < 0.001), TG/HDL-C (p = 0.001), AIP (p < 0.001), SBP (p = 0.01), and DBP (p = 0.04). In normal-weight individuals with low 25-OH- D levels an increased values of glycemia (p = 0.01), insulin resistance (HOMA-IR p = 0.01 and TRYG p = 0.002), TG (p = 0.01), TG/HDL-C (p = 0.02), AIP (p = 0.01). A direct correlation between 25-OH-D levels and metabolic parameters is observed.
A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded. Vitamin D deficiency may represent a preventable and easily treatable cardiometabolic risk factor, emphasizing the importance of early intervention and preventive measures.
•Adequate serum vitamin D levels correlate with a favorable lipid profile.•We explored the impact of vitamin D status on atherogenic dyslipidemia in children with obesity.•A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded.•Vitamin D deficiency may represent a preventable and treatable cardiometabolic risk factor.</description><identifier>ISSN: 0939-4753</identifier><identifier>ISSN: 1590-3729</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2024.07.015</identifier><identifier>PMID: 39168806</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Age Factors ; Atherogenic dyslipidemia ; Atherosclerosis - blood ; Atherosclerosis - diagnosis ; Atherosclerosis - epidemiology ; Biomarkers - blood ; Case-Control Studies ; Child ; Children ; Cross-Sectional Studies ; Dyslipidemias - blood ; Dyslipidemias - diagnosis ; Dyslipidemias - epidemiology ; Female ; Humans ; Lipid profile ; Lipids - blood ; Male ; Pediatric obesity ; Pediatric Obesity - blood ; Pediatric Obesity - diagnosis ; Pediatric Obesity - epidemiology ; Prevalence ; Risk Assessment ; Risk Factors ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - diagnosis ; Vitamin D Deficiency - epidemiology</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2024-11, Vol.34 (11), p.2596-2605</ispartof><rights>2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-ce2068281e06a1be89fc4fb86573d192464ea1810c8b44491ff5bbb5bcab0ede3</cites><orcidid>0000-0002-2137-5974 ; 0000-0003-3128-8441 ; 0009-0002-7025-3348</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2024.07.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39168806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calcaterra, Valeria</creatorcontrib><creatorcontrib>Fabiano, Valentina</creatorcontrib><creatorcontrib>De Silvestri, Annalisa</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><creatorcontrib>Tranfaglia, Valeria</creatorcontrib><creatorcontrib>Loiodice, Martina</creatorcontrib><creatorcontrib>Ceruti, Daniele</creatorcontrib><creatorcontrib>Zuccotti, Gianvincenzo</creatorcontrib><title>The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Adequate serum vitamin D levels correlate with a more favorable lipid profile compared to deficient levels. Despite the well-established prevalence of vitamin D deficiency in children with obesity, studies investigating its influence on lipid profiles in this population are scarce. We explored the impact of vitamin D status on lipid profiles and markers of atherogenic dyslipidemia in a cohort of children and adolescents with obesity.
A total of 271 Caucasian children and adolescents with overweight/obesity and a control group of 54 pediatric patients with normal weight. All participants underwent outpatient visits for the assessment of clinical parameters and venous blood collection for biochemical analysis such as triglycerides (TG)/HDL-C ratio, LDL-C/HDL-C ratio, atherogenic index of plasma AIP), vitamin D level.
Individuals with obesity displayed severe vitamin D deficiency (25-OH-D ≤10 ng/ml) at a higher frequency compared to those with normal weight (p = 0.03). In patients with overweight/obesity and low 25-OH-D levels show higher values of glycemia (p = 0.001), insulin resistance (HOMA-IR and TRYG p < 0.001), TG (p < 0.001), TG/HDL-C (p = 0.001), AIP (p < 0.001), SBP (p = 0.01), and DBP (p = 0.04). In normal-weight individuals with low 25-OH- D levels an increased values of glycemia (p = 0.01), insulin resistance (HOMA-IR p = 0.01 and TRYG p = 0.002), TG (p = 0.01), TG/HDL-C (p = 0.02), AIP (p = 0.01). A direct correlation between 25-OH-D levels and metabolic parameters is observed.
A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded. Vitamin D deficiency may represent a preventable and easily treatable cardiometabolic risk factor, emphasizing the importance of early intervention and preventive measures.
•Adequate serum vitamin D levels correlate with a favorable lipid profile.•We explored the impact of vitamin D status on atherogenic dyslipidemia in children with obesity.•A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded.•Vitamin D deficiency may represent a preventable and treatable cardiometabolic risk factor.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Atherogenic dyslipidemia</subject><subject>Atherosclerosis - blood</subject><subject>Atherosclerosis - diagnosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Children</subject><subject>Cross-Sectional Studies</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - diagnosis</subject><subject>Dyslipidemias - epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Lipid profile</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Pediatric obesity</subject><subject>Pediatric Obesity - blood</subject><subject>Pediatric Obesity - diagnosis</subject><subject>Pediatric Obesity - epidemiology</subject><subject>Prevalence</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - diagnosis</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>0939-4753</issn><issn>1590-3729</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtv1TAQRi1ERS8t_wAhL9kkjGPn4Q0SanlJldi0a8uPCdeXxLnYTtHd8NvrksKS1WzONzPfIeQ1g5oB694d6rDOaF3dQCNq6Gtg7TOyY62EiveNfE52ILmsRN_yc_IypQMA74GLF-ScS9YNA3Q78vt2j9TPR20zXUZ677OefaDXNGWd10SXQCd_9I4e4zL6CRPVwVGd9xiX7xi8pe6U_hA4e01nHX9gTLSssHs_uYhhC7ilZC2GnOgvn_d0MZh8Pl2Ss1FPCV89zQty9-nj7dWX6ubb569XH24q2wiWK4sNdEMzMIROM4ODHK0YzdC1PXdMNqITqNnAwA5GCCHZOLbGmNZYbQAd8gvydttbavxcMWU1-_LONOmAy5oUB9l2fc8EL6jYUBuXlCKO6hh96XVSDNSjeXVQm3n1aF5Br4r5EnvzdGE1M7p_ob-qC_B-A7D0vPcYVbIeg0XnI9qs3OL_f-EB00WZOg</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Calcaterra, Valeria</creator><creator>Fabiano, Valentina</creator><creator>De Silvestri, Annalisa</creator><creator>Colombo, Carla</creator><creator>Tranfaglia, Valeria</creator><creator>Loiodice, Martina</creator><creator>Ceruti, Daniele</creator><creator>Zuccotti, Gianvincenzo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2137-5974</orcidid><orcidid>https://orcid.org/0000-0003-3128-8441</orcidid><orcidid>https://orcid.org/0009-0002-7025-3348</orcidid></search><sort><creationdate>202411</creationdate><title>The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity</title><author>Calcaterra, Valeria ; Fabiano, Valentina ; De Silvestri, Annalisa ; Colombo, Carla ; Tranfaglia, Valeria ; Loiodice, Martina ; Ceruti, Daniele ; Zuccotti, Gianvincenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-ce2068281e06a1be89fc4fb86573d192464ea1810c8b44491ff5bbb5bcab0ede3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Atherogenic dyslipidemia</topic><topic>Atherosclerosis - blood</topic><topic>Atherosclerosis - diagnosis</topic><topic>Atherosclerosis - epidemiology</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Children</topic><topic>Cross-Sectional Studies</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - diagnosis</topic><topic>Dyslipidemias - epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Lipid profile</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Pediatric obesity</topic><topic>Pediatric Obesity - blood</topic><topic>Pediatric Obesity - diagnosis</topic><topic>Pediatric Obesity - epidemiology</topic><topic>Prevalence</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - diagnosis</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calcaterra, Valeria</creatorcontrib><creatorcontrib>Fabiano, Valentina</creatorcontrib><creatorcontrib>De Silvestri, Annalisa</creatorcontrib><creatorcontrib>Colombo, Carla</creatorcontrib><creatorcontrib>Tranfaglia, Valeria</creatorcontrib><creatorcontrib>Loiodice, Martina</creatorcontrib><creatorcontrib>Ceruti, Daniele</creatorcontrib><creatorcontrib>Zuccotti, Gianvincenzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calcaterra, Valeria</au><au>Fabiano, Valentina</au><au>De Silvestri, Annalisa</au><au>Colombo, Carla</au><au>Tranfaglia, Valeria</au><au>Loiodice, Martina</au><au>Ceruti, Daniele</au><au>Zuccotti, Gianvincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2024-11</date><risdate>2024</risdate><volume>34</volume><issue>11</issue><spage>2596</spage><epage>2605</epage><pages>2596-2605</pages><issn>0939-4753</issn><issn>1590-3729</issn><eissn>1590-3729</eissn><abstract>Adequate serum vitamin D levels correlate with a more favorable lipid profile compared to deficient levels. Despite the well-established prevalence of vitamin D deficiency in children with obesity, studies investigating its influence on lipid profiles in this population are scarce. We explored the impact of vitamin D status on lipid profiles and markers of atherogenic dyslipidemia in a cohort of children and adolescents with obesity.
A total of 271 Caucasian children and adolescents with overweight/obesity and a control group of 54 pediatric patients with normal weight. All participants underwent outpatient visits for the assessment of clinical parameters and venous blood collection for biochemical analysis such as triglycerides (TG)/HDL-C ratio, LDL-C/HDL-C ratio, atherogenic index of plasma AIP), vitamin D level.
Individuals with obesity displayed severe vitamin D deficiency (25-OH-D ≤10 ng/ml) at a higher frequency compared to those with normal weight (p = 0.03). In patients with overweight/obesity and low 25-OH-D levels show higher values of glycemia (p = 0.001), insulin resistance (HOMA-IR and TRYG p < 0.001), TG (p < 0.001), TG/HDL-C (p = 0.001), AIP (p < 0.001), SBP (p = 0.01), and DBP (p = 0.04). In normal-weight individuals with low 25-OH- D levels an increased values of glycemia (p = 0.01), insulin resistance (HOMA-IR p = 0.01 and TRYG p = 0.002), TG (p = 0.01), TG/HDL-C (p = 0.02), AIP (p = 0.01). A direct correlation between 25-OH-D levels and metabolic parameters is observed.
A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded. Vitamin D deficiency may represent a preventable and easily treatable cardiometabolic risk factor, emphasizing the importance of early intervention and preventive measures.
•Adequate serum vitamin D levels correlate with a favorable lipid profile.•We explored the impact of vitamin D status on atherogenic dyslipidemia in children with obesity.•A correlation between vitamin D levels and the lipid/atherosclerotic profile was recorded.•Vitamin D deficiency may represent a preventable and treatable cardiometabolic risk factor.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39168806</pmid><doi>10.1016/j.numecd.2024.07.015</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2137-5974</orcidid><orcidid>https://orcid.org/0000-0003-3128-8441</orcidid><orcidid>https://orcid.org/0009-0002-7025-3348</orcidid></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2024-11, Vol.34 (11), p.2596-2605 |
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| subjects | Adolescent Age Factors Atherogenic dyslipidemia Atherosclerosis - blood Atherosclerosis - diagnosis Atherosclerosis - epidemiology Biomarkers - blood Case-Control Studies Child Children Cross-Sectional Studies Dyslipidemias - blood Dyslipidemias - diagnosis Dyslipidemias - epidemiology Female Humans Lipid profile Lipids - blood Male Pediatric obesity Pediatric Obesity - blood Pediatric Obesity - diagnosis Pediatric Obesity - epidemiology Prevalence Risk Assessment Risk Factors Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - epidemiology |
| title | The impact of vitamin D status on lipid profiles and atherogenic dyslipidemia markers in children and adolescents with obesity |
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