Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study
•Patients with PD with constipation had more serious motor and non-motor symptoms.•Emotional and cognitive impairments are related to constipation in patients with PD.•PD patients with constipation have abnormal brain functional activity & connectivity.•Insula and orbitofrontal cortex are involv...
Gespeichert in:
| Veröffentlicht in: | Neuroscience 2024-11, Vol.559, p.17-25 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 25 |
|---|---|
| container_issue | |
| container_start_page | 17 |
| container_title | Neuroscience |
| container_volume | 559 |
| creator | Su, Meilan Wang, Song Cheng, Oumei Xie, Kai Peng, Juan Du, Xinyi Huang, Lei Feng, Tian |
| description | •Patients with PD with constipation had more serious motor and non-motor symptoms.•Emotional and cognitive impairments are related to constipation in patients with PD.•PD patients with constipation have abnormal brain functional activity & connectivity.•Insula and orbitofrontal cortex are involved in the regulation of constipation in PD.
Constipation frequently occurs in patients with Parkinson’s disease (PD) and may be related to cognitive and emotional disorders. The aim of this study is to investigate the clinical and brain functional characteristics of patients with PD presenting with constipation.
The motor and non-motor symptoms of patients with PD were evaluated, and a resting-state functional magnetic resonance imaging (RS-fMRI) study was conducted based on propensity score matching. Alterations in brain function were analyzed using regional homogeneity (ReHo) and functional connectivity (FC).
Compared with patients without constipation (PD-NC group), patients with constipation (PD-C group) had more serious motor and non-motor symptoms (including cognitive and emotional disorders along with visual hallucinations). Further, emotional and cognitive disorders were correlated with the occurrence of constipation in patients with PD. Compared with the PD-NC group, the PD-C group showed a reduced ReHo of the right insula and bilateral orbitofrontal cortex (OFC), increased ReHo of the left postcentral gyrus, and enhanced FC between the right OFC and the left middle temporal gyrus (MTG) and middle occipital gyrus (MOG). Additionally, the activity of the OFC and insula was significantly correlated with the constipation, mood, and cognitive levels of patients with PD.
Constipation in patients with PD is closely related to emotional and cognitive impairments, abnormal activity and FC of brain regions such as the right insula and bilateral OFC may play an important role in this. |
| doi_str_mv | 10.1016/j.neuroscience.2024.08.027 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3095675490</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0306452224004135</els_id><sourcerecordid>3095675490</sourcerecordid><originalsourceid>FETCH-LOGICAL-c305t-4e8191f697c6935daa5da15c91c16490b7135cd56140653d930653044753d7a03</originalsourceid><addsrcrecordid>eNqNUc2OFCEQJkbjzq6-giGevHQLDfTP3jazuppsogc9EwZqtMZuGIFeszcfwauv55NIZ1rjUZJKUeH7CfUR8pyzmjPevjzUHuYYkkXwFuqGNbJmfc2a7gHZ8L4TVaekfEg2TLC2kqppzsh5SgdWjpLiMTkTA2973skN-bENPmU8mozBU0zUpBQsmgyOfsP8mcIUliczUuMdteGTx4x3QHE6GowT-EzR04VfrunEeW_iF_Qp-F_ffybqMIFJcEmvqB3Ro121dtEU5n72djVIeXb3T8ijvRkTPF37Bfn4-tWH7Zvq9t3N2-3VbWUFU7mS0POB79uhs-0glDOmFFd24Ja3cmC7jgtlnWq5ZK0SbhBLY1J2ZegMExfkxUn3GMPXGVLWEyYL42g8hDlpwQbVlj0OC_TyBLVl6SnCXh8jTibea870kog-6H8T0UsimvW6JFLIz1afeTeB-0v9E0EBXJ8AUH57hxD1KuMwgs3aBfwfn98xJ6b2</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3095675490</pqid></control><display><type>article</type><title>Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study</title><source>ScienceDirect Journals (5 years ago - present)</source><creator>Su, Meilan ; Wang, Song ; Cheng, Oumei ; Xie, Kai ; Peng, Juan ; Du, Xinyi ; Huang, Lei ; Feng, Tian</creator><creatorcontrib>Su, Meilan ; Wang, Song ; Cheng, Oumei ; Xie, Kai ; Peng, Juan ; Du, Xinyi ; Huang, Lei ; Feng, Tian</creatorcontrib><description>•Patients with PD with constipation had more serious motor and non-motor symptoms.•Emotional and cognitive impairments are related to constipation in patients with PD.•PD patients with constipation have abnormal brain functional activity & connectivity.•Insula and orbitofrontal cortex are involved in the regulation of constipation in PD.
Constipation frequently occurs in patients with Parkinson’s disease (PD) and may be related to cognitive and emotional disorders. The aim of this study is to investigate the clinical and brain functional characteristics of patients with PD presenting with constipation.
The motor and non-motor symptoms of patients with PD were evaluated, and a resting-state functional magnetic resonance imaging (RS-fMRI) study was conducted based on propensity score matching. Alterations in brain function were analyzed using regional homogeneity (ReHo) and functional connectivity (FC).
Compared with patients without constipation (PD-NC group), patients with constipation (PD-C group) had more serious motor and non-motor symptoms (including cognitive and emotional disorders along with visual hallucinations). Further, emotional and cognitive disorders were correlated with the occurrence of constipation in patients with PD. Compared with the PD-NC group, the PD-C group showed a reduced ReHo of the right insula and bilateral orbitofrontal cortex (OFC), increased ReHo of the left postcentral gyrus, and enhanced FC between the right OFC and the left middle temporal gyrus (MTG) and middle occipital gyrus (MOG). Additionally, the activity of the OFC and insula was significantly correlated with the constipation, mood, and cognitive levels of patients with PD.
Constipation in patients with PD is closely related to emotional and cognitive impairments, abnormal activity and FC of brain regions such as the right insula and bilateral OFC may play an important role in this.</description><identifier>ISSN: 0306-4522</identifier><identifier>ISSN: 1873-7544</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2024.08.027</identifier><identifier>PMID: 39168174</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cognition ; Constipation ; Functional magnetic resonance imaging ; Mood ; Parkinson’s disease</subject><ispartof>Neuroscience, 2024-11, Vol.559, p.17-25</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-4e8191f697c6935daa5da15c91c16490b7135cd56140653d930653044753d7a03</cites><orcidid>0000-0002-1889-6541</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2024.08.027$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39168174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Meilan</creatorcontrib><creatorcontrib>Wang, Song</creatorcontrib><creatorcontrib>Cheng, Oumei</creatorcontrib><creatorcontrib>Xie, Kai</creatorcontrib><creatorcontrib>Peng, Juan</creatorcontrib><creatorcontrib>Du, Xinyi</creatorcontrib><creatorcontrib>Huang, Lei</creatorcontrib><creatorcontrib>Feng, Tian</creatorcontrib><title>Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>•Patients with PD with constipation had more serious motor and non-motor symptoms.•Emotional and cognitive impairments are related to constipation in patients with PD.•PD patients with constipation have abnormal brain functional activity & connectivity.•Insula and orbitofrontal cortex are involved in the regulation of constipation in PD.
Constipation frequently occurs in patients with Parkinson’s disease (PD) and may be related to cognitive and emotional disorders. The aim of this study is to investigate the clinical and brain functional characteristics of patients with PD presenting with constipation.
The motor and non-motor symptoms of patients with PD were evaluated, and a resting-state functional magnetic resonance imaging (RS-fMRI) study was conducted based on propensity score matching. Alterations in brain function were analyzed using regional homogeneity (ReHo) and functional connectivity (FC).
Compared with patients without constipation (PD-NC group), patients with constipation (PD-C group) had more serious motor and non-motor symptoms (including cognitive and emotional disorders along with visual hallucinations). Further, emotional and cognitive disorders were correlated with the occurrence of constipation in patients with PD. Compared with the PD-NC group, the PD-C group showed a reduced ReHo of the right insula and bilateral orbitofrontal cortex (OFC), increased ReHo of the left postcentral gyrus, and enhanced FC between the right OFC and the left middle temporal gyrus (MTG) and middle occipital gyrus (MOG). Additionally, the activity of the OFC and insula was significantly correlated with the constipation, mood, and cognitive levels of patients with PD.
Constipation in patients with PD is closely related to emotional and cognitive impairments, abnormal activity and FC of brain regions such as the right insula and bilateral OFC may play an important role in this.</description><subject>Cognition</subject><subject>Constipation</subject><subject>Functional magnetic resonance imaging</subject><subject>Mood</subject><subject>Parkinson’s disease</subject><issn>0306-4522</issn><issn>1873-7544</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqNUc2OFCEQJkbjzq6-giGevHQLDfTP3jazuppsogc9EwZqtMZuGIFeszcfwauv55NIZ1rjUZJKUeH7CfUR8pyzmjPevjzUHuYYkkXwFuqGNbJmfc2a7gHZ8L4TVaekfEg2TLC2kqppzsh5SgdWjpLiMTkTA2973skN-bENPmU8mozBU0zUpBQsmgyOfsP8mcIUliczUuMdteGTx4x3QHE6GowT-EzR04VfrunEeW_iF_Qp-F_ffybqMIFJcEmvqB3Ro121dtEU5n72djVIeXb3T8ijvRkTPF37Bfn4-tWH7Zvq9t3N2-3VbWUFU7mS0POB79uhs-0glDOmFFd24Ja3cmC7jgtlnWq5ZK0SbhBLY1J2ZegMExfkxUn3GMPXGVLWEyYL42g8hDlpwQbVlj0OC_TyBLVl6SnCXh8jTibea870kog-6H8T0UsimvW6JFLIz1afeTeB-0v9E0EBXJ8AUH57hxD1KuMwgs3aBfwfn98xJ6b2</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Su, Meilan</creator><creator>Wang, Song</creator><creator>Cheng, Oumei</creator><creator>Xie, Kai</creator><creator>Peng, Juan</creator><creator>Du, Xinyi</creator><creator>Huang, Lei</creator><creator>Feng, Tian</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1889-6541</orcidid></search><sort><creationdate>20241101</creationdate><title>Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study</title><author>Su, Meilan ; Wang, Song ; Cheng, Oumei ; Xie, Kai ; Peng, Juan ; Du, Xinyi ; Huang, Lei ; Feng, Tian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-4e8191f697c6935daa5da15c91c16490b7135cd56140653d930653044753d7a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Cognition</topic><topic>Constipation</topic><topic>Functional magnetic resonance imaging</topic><topic>Mood</topic><topic>Parkinson’s disease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Meilan</creatorcontrib><creatorcontrib>Wang, Song</creatorcontrib><creatorcontrib>Cheng, Oumei</creatorcontrib><creatorcontrib>Xie, Kai</creatorcontrib><creatorcontrib>Peng, Juan</creatorcontrib><creatorcontrib>Du, Xinyi</creatorcontrib><creatorcontrib>Huang, Lei</creatorcontrib><creatorcontrib>Feng, Tian</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Meilan</au><au>Wang, Song</au><au>Cheng, Oumei</au><au>Xie, Kai</au><au>Peng, Juan</au><au>Du, Xinyi</au><au>Huang, Lei</au><au>Feng, Tian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>559</volume><spage>17</spage><epage>25</epage><pages>17-25</pages><issn>0306-4522</issn><issn>1873-7544</issn><eissn>1873-7544</eissn><abstract>•Patients with PD with constipation had more serious motor and non-motor symptoms.•Emotional and cognitive impairments are related to constipation in patients with PD.•PD patients with constipation have abnormal brain functional activity & connectivity.•Insula and orbitofrontal cortex are involved in the regulation of constipation in PD.
Constipation frequently occurs in patients with Parkinson’s disease (PD) and may be related to cognitive and emotional disorders. The aim of this study is to investigate the clinical and brain functional characteristics of patients with PD presenting with constipation.
The motor and non-motor symptoms of patients with PD were evaluated, and a resting-state functional magnetic resonance imaging (RS-fMRI) study was conducted based on propensity score matching. Alterations in brain function were analyzed using regional homogeneity (ReHo) and functional connectivity (FC).
Compared with patients without constipation (PD-NC group), patients with constipation (PD-C group) had more serious motor and non-motor symptoms (including cognitive and emotional disorders along with visual hallucinations). Further, emotional and cognitive disorders were correlated with the occurrence of constipation in patients with PD. Compared with the PD-NC group, the PD-C group showed a reduced ReHo of the right insula and bilateral orbitofrontal cortex (OFC), increased ReHo of the left postcentral gyrus, and enhanced FC between the right OFC and the left middle temporal gyrus (MTG) and middle occipital gyrus (MOG). Additionally, the activity of the OFC and insula was significantly correlated with the constipation, mood, and cognitive levels of patients with PD.
Constipation in patients with PD is closely related to emotional and cognitive impairments, abnormal activity and FC of brain regions such as the right insula and bilateral OFC may play an important role in this.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39168174</pmid><doi>10.1016/j.neuroscience.2024.08.027</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1889-6541</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-4522 |
| ispartof | Neuroscience, 2024-11, Vol.559, p.17-25 |
| issn | 0306-4522 1873-7544 1873-7544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3095675490 |
| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Cognition Constipation Functional magnetic resonance imaging Mood Parkinson’s disease |
| title | Constipation is associated with emotional and cognitive impairment in patients with Parkinson’s disease: A clinical and brain functional study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T16%3A16%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Constipation%20is%20associated%20with%20emotional%20and%20cognitive%20impairment%20in%20patients%20with%20Parkinson%E2%80%99s%20disease:%20A%20clinical%20and%20brain%20functional%20study&rft.jtitle=Neuroscience&rft.au=Su,%20Meilan&rft.date=2024-11-01&rft.volume=559&rft.spage=17&rft.epage=25&rft.pages=17-25&rft.issn=0306-4522&rft.eissn=1873-7544&rft_id=info:doi/10.1016/j.neuroscience.2024.08.027&rft_dat=%3Cproquest_cross%3E3095675490%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3095675490&rft_id=info:pmid/39168174&rft_els_id=S0306452224004135&rfr_iscdi=true |