Ex vivo T cell differentiation in adoptive immunotherapy manufacturing: Critical process parameters and analytical technologies

Adoptive immunotherapy shows great promise as a treatment for cancer and other diseases. Recent evidence suggests that the therapeutic efficacy of these cell-based therapies can be enhanced by the enrichment of less-differentiated T cell subpopulations in the therapeutic product, giving rise to a ne...

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Veröffentlicht in:	Biotechnology advances 2024-12, Vol.77, p.108434, Article 108434
Hauptverfasser:	Chen, Sixun, Nguyen, Tan Dai, Lee, Kang-Zheng, Liu, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adoptive immunotherapy manufacturing Analytical technologies Animals Cell Culture Techniques - methods Cell Differentiation Critical process parameters (CPPs) Cytokines - metabolism Humans Immunotherapy, Adoptive - methods Process analytical technologies (PATs) T cell differentiation T-Lymphocytes - cytology T-Lymphocytes - immunology
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