Discovery and Profiling of New Multimodal Phenylglycinamide Derivatives as Potent Antiseizure and Antinociceptive Drug Candidates

We developed a focused series of original phenyl-glycinamide derivatives which showed potent activity across in vivo mouse seizure models, namely, maximal electroshock (MES) and 6 Hz (using both 32 and 44 mA current intensities) seizure models. Following intraperitoneal (i.p.) administration, compou...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	ACS chemical neuroscience 2024-09, Vol.15 (17), p.3228-3256
Hauptverfasser:	Jakubiec, Marcin, Abram, Michał, Zagaja, Mirosław, Socała, Katarzyna, Panic, Vanja, Latacz, Gniewomir, Mogilski, Szczepan, Szafarz, Małgorzata, Szala-Rycaj, Joanna, Saunders, Jerry, West, Peter J., Nieoczym, Dorota, Przejczowska-Pomierny, Katarzyna, Szulczyk, Bartłomiej, Krupa, Anna, Wyska, Elżbieta, Wlaź, Piotr, Metcalf, Cameron S., Wilcox, Karen, Andres-Mach, Marta, Kamiński, Rafał M., Kamiński, Krzysztof
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Anticonvulsants - chemistry Anticonvulsants - pharmacology Brain-Derived Neurotrophic Factor - metabolism Disease Models, Animal Drug Discovery Electroshock Glycine - analogs & derivatives Glycine - chemistry Glycine - pharmacology Hippocampus - drug effects Hippocampus - metabolism Humans Kindling, Neurologic - drug effects Male Mice Pain - drug therapy Pentylenetetrazole Seizures - drug therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!