Randomized Crossover Trial of 2-Week Ketone Ester Treatment in Patients With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality in patients with type 2 diabetes (T2D). Acute increases in circulating levels of ketone body 3-hydroxybutyrate have beneficial acute hemodynamic effects in patients without T2D with chronic heart failu...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2024-11, Vol.150 (20), p.1570-1583
Hauptverfasser:	Gopalasingam, Nigopan, Berg-Hansen, Kristoffer, Christensen, Kristian Hylleberg, Ladefoged, Bertil T, Poulsen, Steen Hvitfeldt, Andersen, Mads Jønsson, Borlaug, Barry A, Nielsen, Roni, Møller, Niels, Wiggers, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Hydroxybutyric Acid - blood Aged Cardiac Output - drug effects Cross-Over Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - physiopathology Double-Blind Method Esters Female Heart Failure - drug therapy Heart Failure - physiopathology Humans Male Middle Aged Stroke Volume - drug effects Treatment Outcome Ventricular Function, Left - drug effects
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