Comparison of clinical selection-based genetic testing with phenotype-agnostic extensive germline sequencing to diagnose genetic predisposition in children with cancer: a prospective diagnostic study

Germline data have become widely available in paediatric oncology since the introduction of paired tumour-germline sequencing. To guide best practice in cancer predisposition syndrome (CPS) diagnostics, we aimed to assess the diagnostic yield of extensive germline analysis compared with clinical sel...

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Veröffentlicht in:	The lancet child & adolescent health 2024-10, Vol.8 (10), p.751-761
Hauptverfasser:	Bakhuizen, Jette J, van Dijk, Freerk, Koudijs, Marco J, Bladergroen, Reno S, Bon, Sebastian B B, Hopman, Saskia M J, Kester, Lennart A, Kranendonk, Mariëtte E G, Loeffen, Jan L C, Smetsers, Stephanie E, Sonneveld, Edwin, Tachdjian, Melissa, de Vos-Kerkhof, Evelien, Goudie, Catherine, Merks, Johannes H M, Kuiper, Roland P, Jongmans, Marjolijn C J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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