Prognostic impact of enhanced CD96 expression on NK cells by TGF-β1 in AML

•Increased CD96 expression on NK cells: AML patients show enhanced CD96 expression on NK cells at initial diagnosis, indicating a dysfunctional NK cell phenotype.•CD96 blockade enhances NK cell cytotoxicity: Blocking CD96 significantly improves NK cell cytotoxicity against leukemia cells, suggesting...

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Veröffentlicht in:	International immunopharmacology 2024-11, Vol.141, p.112958, Article 112958
Hauptverfasser:	Zhang, Qi, Huang, Ting, Li, Xiaomin, Liu, Guanfang, Xian, Luhua, Mao, Xueying, Lin, Ting, Fu, Cheng, Chen, Xiangming, Liang, Wenting, Zheng, Yanling, Zhao, Yuyang, Lin, Qiwen, Xu, Xiuzhang, Lin, Yu, Bu, Jin, Wu, Changyou, Zhou, Maohua, Shen, Erxia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AML Antigens, CD - metabolism CD96 Cell Line, Tumor Cytotoxicity, Immunologic Female Humans Interferon-gamma - metabolism Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - immunology Male Middle Aged Prognosis Signal Transduction Smad3 Protein - metabolism TGF-β Transforming Growth Factor beta1 - metabolism Young Adult
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