Synthetic polypeptides inhibit nucleic acid-induced inflammation in autoimmune diseases by disrupting multivalent TLR9 binding to LL37-DNA bundles

Complexes of extracellular nucleic acids (NAs) with endogenous proteins or peptides, such as LL37, break immune balance and cause autoimmune diseases, whereas NAs with arginine-enriched peptides do not. Inspired by this, we synthesize a polyarginine nanoparticle PEG- TK -NP Arg , which effectively i...

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Veröffentlicht in:	Nature nanotechnology 2024-11, Vol.19 (11), p.1745-1756
Hauptverfasser:	Liu, Xingliang, Chen, Shi, Huang, Jing, Du, Yibo, Luo, Zhi, Zhang, Yue, Liu, Lixin, Chen, Yongming
Format:	Artikel
Sprache:	eng
Schlagworte:	140/131 639/301/54 639/925/357/354 Amino acid composition Amino acids Animal models Animals Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - metabolism Autoimmune diseases Autoimmune Diseases - drug therapy Cathelicidins - chemistry Chemistry and Materials Science Clustering Composition effects Damping DNA - chemistry Humans Immune response Immune system Inflammation Inflammation - chemically induced Materials Science Mice Nanoparticles Nanoparticles - chemistry Nanotechnology Nanotechnology and Microengineering Nucleic acids Nucleic Acids - chemistry Nucleic Acids - pharmacology Peptides Peptides - chemistry Peptides - pharmacology Periodic structures Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polypeptides Proteins Rheumatoid arthritis Scavenging TLR9 protein Toll-Like Receptor 9 - metabolism Toll-like receptors Topology X-ray scattering
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