The Evolving Portrait of γδ TCR Recognition Determinants

In αβ T cells, immunosurveillance is enabled by the αβ TCR, which corecognizes peptide, lipid, or small-molecule Ags presented by MHC- and MHC class I-like Ag-presenting molecules, respectively. Although αβ TCRs vary in their Ag recognition modes, in general they corecognize the presented Ag and the...

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Veröffentlicht in:The Journal of immunology (1950) 2024-09, Vol.213 (5), p.543
Hauptverfasser: Sok, Chhon Ling, Rossjohn, Jamie, Gully, Benjamin S
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container_title The Journal of immunology (1950)
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creator Sok, Chhon Ling
Rossjohn, Jamie
Gully, Benjamin S
description In αβ T cells, immunosurveillance is enabled by the αβ TCR, which corecognizes peptide, lipid, or small-molecule Ags presented by MHC- and MHC class I-like Ag-presenting molecules, respectively. Although αβ TCRs vary in their Ag recognition modes, in general they corecognize the presented Ag and the Ag-presenting molecule and do so in an invariable "end-to-end" manner. Quite distinctly, γδ T cells, by way of their γδ TCR, can recognize ligands that extend beyond the confines of MHC- and MHC class I-like restrictions. From structural studies, it is now becoming apparent that γδ TCR recognition modes can break the corecognition paradigm and deviate markedly from the end-to-end docking mechanisms of αβ TCR counterparts. This brief review highlights the emerging portrait of how γδ TCRs can recognize diverse epitopes of their Ags in a manner reminiscent to how Abs recognize Ags.
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subjects Animals
Antigen Presentation - immunology
Epitopes, T-Lymphocyte - immunology
Humans
Receptors, Antigen, T-Cell, alpha-beta - immunology
Receptors, Antigen, T-Cell, alpha-beta - metabolism
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocytes - immunology
title The Evolving Portrait of γδ TCR Recognition Determinants
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