The Antidepressant- and Anxiolytic-Like Effects of the Phosphodiesterase Type-5 Inhibitor Tadalafil are Associated with the Modulation of the Gut-Brain Axis During CNS Autoimmunity

Multiple Sclerosis (MS) is a debilitating disease that severely affects the central nervous system (CNS). Apart from neurological symptoms, it is also characterized by neuropsychiatric comorbidities, such as anxiety and depression. Phosphodiesterase-5 inhibitors (PDE5Is) such as Sildenafil and Tadal...

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Veröffentlicht in:	Journal of neuroimmune pharmacology 2024-08, Vol.19 (1), p.45
Hauptverfasser:	Duarte-Silva, Eduardo, Oriá, Alice Chevrollier, Mendonça, Ingrid Prata, Paiva, Igor Henrique Rodrigues, Leuthier dos Santos, Klyvia, Sales, Amanda Juliana, de Souza, José Roberto Botelho, Maes, Michael, Meuth, Sven Guenther, Peixoto, Christina Alves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - administration & dosage Antidepressants Antidepressive Agents - administration & dosage Autoimmunity - drug effects Behavior Biomedical and Life Sciences Biomedicine Brain-Gut Axis - drug effects Cell Biology Depression - drug therapy Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - immunology Female Gastrointestinal Microbiome - drug effects Immunology Mice Mice, Inbred C57BL Microbiota Neurosciences Permeability Pharmacology/Toxicology Phosphodiesterase 5 Inhibitors - administration & dosage Tadalafil - administration & dosage Virology
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