Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge

Metals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been fo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry : a European journal 2024-10, Vol.30 (60), p.e202402647-n/a
Hauptverfasser: Cirri, Damiano, Di Leo, Riccardo, Chiaverini, Lorenzo, Tolbatov, Iogann, Marrone, Alessandro, Messori, Luigi, Pratesi, Alessandro, La Mendola, Diego, Marzo, Tiziano
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page n/a
container_issue 60
container_start_page e202402647
container_title Chemistry : a European journal
container_volume 30
creator Cirri, Damiano
Di Leo, Riccardo
Chiaverini, Lorenzo
Tolbatov, Iogann
Marrone, Alessandro
Messori, Luigi
Pratesi, Alessandro
La Mendola, Diego
Marzo, Tiziano
description Metals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been found that there is probably no single biological target for the pharmacological effects of most inorganic drugs. Herein, we present an overview of some integrated and multi‐technique approaches to elucidate the molecular interactions underlying the biological effects of metallodrugs. On this premise, selected examples are used to illustrate how the information obtained on metal‐based drugs and their respective mechanisms can become relevant for applications in fields other than medicine. For example, some well‐known metallodrugs, which have been shown to bind specific amino acid residues of proteins, can be used to solve problems related to protein structure elucidation in crystallographic studies. Diruthenium tetraacetate can be used to catalyze the conversion of hydroxylamines to nitrones with a high selectivity when bound to lysozyme. Finally, a case study is presented in which an unprecedented palladium/arsenic‐mediated catalytic cycle for nitrile hydration was discovered thanks to previous studies on the solution chemistry of the anticancer compound arsenoplatin‐1 (AP‐1). Starting from the description of integrated approaches for unveiling the molecular interactions underlying the biological effects of metallodrugs, through selected examples, it is highlighted how the obtained mechanistic information may turn relevant for the application of inorganic drugs in fields different from medicine.
doi_str_mv 10.1002/chem.202402647
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3094472657</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3094472657</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2987-a4a162648e7b9f134d42915bbf609d06d22a4c99fa5ba0b1572dd5dbbf8da95a3</originalsourceid><addsrcrecordid>eNqFkLtOwzAUhi0EglJYGVEkFpYE3xOPpSpQQWEAFhbLsR2aKrVL3Khi4xF4Rp4EQ7lILEznSOc7v359ABwgmCEI8Yme2nmGIaYQc5pvgB5iGKUk52wT9KCgecoZETtgN4QZhFBwQrbBDhGIFQjRHni49u7t5XViTa1VkwwWiyYuy9q7kPgqGTvfPipX6-STqJ0NWTJIblf1Uk-TUxWsSbyLRz2NVFhG8NL5VWPNo90DW5Vqgt3_mn1wfza6G16kVzfn4-HgKtVYFHmqqEI8li9sXooKEWoojvXKsuJQGMgNxopqISrFSgVLxHJsDDPxXhglmCJ9cLzOXbT-qbNhKed10LZplLO-C5JEDTTHnOURPfqDznzXuthOEoQRii0gj1S2pnTrQ2htJRdtPVfts0RQfliXH9blj_X4cPgV25Vza37wb80REGtgVTf2-Z84ObwYTX7D3wGjzI5T</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3121164806</pqid></control><display><type>article</type><title>Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Cirri, Damiano ; Di Leo, Riccardo ; Chiaverini, Lorenzo ; Tolbatov, Iogann ; Marrone, Alessandro ; Messori, Luigi ; Pratesi, Alessandro ; La Mendola, Diego ; Marzo, Tiziano</creator><creatorcontrib>Cirri, Damiano ; Di Leo, Riccardo ; Chiaverini, Lorenzo ; Tolbatov, Iogann ; Marrone, Alessandro ; Messori, Luigi ; Pratesi, Alessandro ; La Mendola, Diego ; Marzo, Tiziano</creatorcontrib><description>Metals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been found that there is probably no single biological target for the pharmacological effects of most inorganic drugs. Herein, we present an overview of some integrated and multi‐technique approaches to elucidate the molecular interactions underlying the biological effects of metallodrugs. On this premise, selected examples are used to illustrate how the information obtained on metal‐based drugs and their respective mechanisms can become relevant for applications in fields other than medicine. For example, some well‐known metallodrugs, which have been shown to bind specific amino acid residues of proteins, can be used to solve problems related to protein structure elucidation in crystallographic studies. Diruthenium tetraacetate can be used to catalyze the conversion of hydroxylamines to nitrones with a high selectivity when bound to lysozyme. Finally, a case study is presented in which an unprecedented palladium/arsenic‐mediated catalytic cycle for nitrile hydration was discovered thanks to previous studies on the solution chemistry of the anticancer compound arsenoplatin‐1 (AP‐1). Starting from the description of integrated approaches for unveiling the molecular interactions underlying the biological effects of metallodrugs, through selected examples, it is highlighted how the obtained mechanistic information may turn relevant for the application of inorganic drugs in fields different from medicine.</description><identifier>ISSN: 0947-6539</identifier><identifier>ISSN: 1521-3765</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.202402647</identifier><identifier>PMID: 39158114</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Amino acids ; Antineoplastic Agents - chemistry ; Antineoplastic Agents - pharmacology ; Arsenic ; Arsenic - chemistry ; Arsenic compounds ; Biological effects ; Cancer ; Catalysis ; Catalytic converters ; Coordination Complexes - chemistry ; Crystallography ; Drug interaction ; Drug repurposing ; Drugs ; Heavy metals ; Humans ; Lysozyme ; Mass spectrometry ; Metallodrugs ; Molecular interactions ; Muramidase - chemistry ; Muramidase - metabolism ; Palladium ; Palladium - chemistry ; Protein structure ; Proteins ; X-ray crystallography</subject><ispartof>Chemistry : a European journal, 2024-10, Vol.30 (60), p.e202402647-n/a</ispartof><rights>2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH</rights><rights>2024 The Author(s). Chemistry - A European Journal published by Wiley-VCH GmbH.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2987-a4a162648e7b9f134d42915bbf609d06d22a4c99fa5ba0b1572dd5dbbf8da95a3</cites><orcidid>0000-0002-5051-1584 ; 0000-0003-4857-9819 ; 0000-0002-4193-7612 ; 0000-0002-8311-8172 ; 0000-0002-9490-8014 ; 0000-0001-9175-9562 ; 0000-0002-9553-9943 ; 0000-0002-2567-3637 ; 0000-0001-9700-5331</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.202402647$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.202402647$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39158114$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cirri, Damiano</creatorcontrib><creatorcontrib>Di Leo, Riccardo</creatorcontrib><creatorcontrib>Chiaverini, Lorenzo</creatorcontrib><creatorcontrib>Tolbatov, Iogann</creatorcontrib><creatorcontrib>Marrone, Alessandro</creatorcontrib><creatorcontrib>Messori, Luigi</creatorcontrib><creatorcontrib>Pratesi, Alessandro</creatorcontrib><creatorcontrib>La Mendola, Diego</creatorcontrib><creatorcontrib>Marzo, Tiziano</creatorcontrib><title>Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge</title><title>Chemistry : a European journal</title><addtitle>Chemistry</addtitle><description>Metals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been found that there is probably no single biological target for the pharmacological effects of most inorganic drugs. Herein, we present an overview of some integrated and multi‐technique approaches to elucidate the molecular interactions underlying the biological effects of metallodrugs. On this premise, selected examples are used to illustrate how the information obtained on metal‐based drugs and their respective mechanisms can become relevant for applications in fields other than medicine. For example, some well‐known metallodrugs, which have been shown to bind specific amino acid residues of proteins, can be used to solve problems related to protein structure elucidation in crystallographic studies. Diruthenium tetraacetate can be used to catalyze the conversion of hydroxylamines to nitrones with a high selectivity when bound to lysozyme. Finally, a case study is presented in which an unprecedented palladium/arsenic‐mediated catalytic cycle for nitrile hydration was discovered thanks to previous studies on the solution chemistry of the anticancer compound arsenoplatin‐1 (AP‐1). Starting from the description of integrated approaches for unveiling the molecular interactions underlying the biological effects of metallodrugs, through selected examples, it is highlighted how the obtained mechanistic information may turn relevant for the application of inorganic drugs in fields different from medicine.</description><subject>Amino acids</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Arsenic</subject><subject>Arsenic - chemistry</subject><subject>Arsenic compounds</subject><subject>Biological effects</subject><subject>Cancer</subject><subject>Catalysis</subject><subject>Catalytic converters</subject><subject>Coordination Complexes - chemistry</subject><subject>Crystallography</subject><subject>Drug interaction</subject><subject>Drug repurposing</subject><subject>Drugs</subject><subject>Heavy metals</subject><subject>Humans</subject><subject>Lysozyme</subject><subject>Mass spectrometry</subject><subject>Metallodrugs</subject><subject>Molecular interactions</subject><subject>Muramidase - chemistry</subject><subject>Muramidase - metabolism</subject><subject>Palladium</subject><subject>Palladium - chemistry</subject><subject>Protein structure</subject><subject>Proteins</subject><subject>X-ray crystallography</subject><issn>0947-6539</issn><issn>1521-3765</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkLtOwzAUhi0EglJYGVEkFpYE3xOPpSpQQWEAFhbLsR2aKrVL3Khi4xF4Rp4EQ7lILEznSOc7v359ABwgmCEI8Yme2nmGIaYQc5pvgB5iGKUk52wT9KCgecoZETtgN4QZhFBwQrbBDhGIFQjRHni49u7t5XViTa1VkwwWiyYuy9q7kPgqGTvfPipX6-STqJ0NWTJIblf1Uk-TUxWsSbyLRz2NVFhG8NL5VWPNo90DW5Vqgt3_mn1wfza6G16kVzfn4-HgKtVYFHmqqEI8li9sXooKEWoojvXKsuJQGMgNxopqISrFSgVLxHJsDDPxXhglmCJ9cLzOXbT-qbNhKed10LZplLO-C5JEDTTHnOURPfqDznzXuthOEoQRii0gj1S2pnTrQ2htJRdtPVfts0RQfliXH9blj_X4cPgV25Vza37wb80REGtgVTf2-Z84ObwYTX7D3wGjzI5T</recordid><startdate>20241028</startdate><enddate>20241028</enddate><creator>Cirri, Damiano</creator><creator>Di Leo, Riccardo</creator><creator>Chiaverini, Lorenzo</creator><creator>Tolbatov, Iogann</creator><creator>Marrone, Alessandro</creator><creator>Messori, Luigi</creator><creator>Pratesi, Alessandro</creator><creator>La Mendola, Diego</creator><creator>Marzo, Tiziano</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5051-1584</orcidid><orcidid>https://orcid.org/0000-0003-4857-9819</orcidid><orcidid>https://orcid.org/0000-0002-4193-7612</orcidid><orcidid>https://orcid.org/0000-0002-8311-8172</orcidid><orcidid>https://orcid.org/0000-0002-9490-8014</orcidid><orcidid>https://orcid.org/0000-0001-9175-9562</orcidid><orcidid>https://orcid.org/0000-0002-9553-9943</orcidid><orcidid>https://orcid.org/0000-0002-2567-3637</orcidid><orcidid>https://orcid.org/0000-0001-9700-5331</orcidid></search><sort><creationdate>20241028</creationdate><title>Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge</title><author>Cirri, Damiano ; Di Leo, Riccardo ; Chiaverini, Lorenzo ; Tolbatov, Iogann ; Marrone, Alessandro ; Messori, Luigi ; Pratesi, Alessandro ; La Mendola, Diego ; Marzo, Tiziano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2987-a4a162648e7b9f134d42915bbf609d06d22a4c99fa5ba0b1572dd5dbbf8da95a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Amino acids</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Arsenic</topic><topic>Arsenic - chemistry</topic><topic>Arsenic compounds</topic><topic>Biological effects</topic><topic>Cancer</topic><topic>Catalysis</topic><topic>Catalytic converters</topic><topic>Coordination Complexes - chemistry</topic><topic>Crystallography</topic><topic>Drug interaction</topic><topic>Drug repurposing</topic><topic>Drugs</topic><topic>Heavy metals</topic><topic>Humans</topic><topic>Lysozyme</topic><topic>Mass spectrometry</topic><topic>Metallodrugs</topic><topic>Molecular interactions</topic><topic>Muramidase - chemistry</topic><topic>Muramidase - metabolism</topic><topic>Palladium</topic><topic>Palladium - chemistry</topic><topic>Protein structure</topic><topic>Proteins</topic><topic>X-ray crystallography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cirri, Damiano</creatorcontrib><creatorcontrib>Di Leo, Riccardo</creatorcontrib><creatorcontrib>Chiaverini, Lorenzo</creatorcontrib><creatorcontrib>Tolbatov, Iogann</creatorcontrib><creatorcontrib>Marrone, Alessandro</creatorcontrib><creatorcontrib>Messori, Luigi</creatorcontrib><creatorcontrib>Pratesi, Alessandro</creatorcontrib><creatorcontrib>La Mendola, Diego</creatorcontrib><creatorcontrib>Marzo, Tiziano</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cirri, Damiano</au><au>Di Leo, Riccardo</au><au>Chiaverini, Lorenzo</au><au>Tolbatov, Iogann</au><au>Marrone, Alessandro</au><au>Messori, Luigi</au><au>Pratesi, Alessandro</au><au>La Mendola, Diego</au><au>Marzo, Tiziano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chemistry</addtitle><date>2024-10-28</date><risdate>2024</risdate><volume>30</volume><issue>60</issue><spage>e202402647</spage><epage>n/a</epage><pages>e202402647-n/a</pages><issn>0947-6539</issn><issn>1521-3765</issn><eissn>1521-3765</eissn><abstract>Metals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been found that there is probably no single biological target for the pharmacological effects of most inorganic drugs. Herein, we present an overview of some integrated and multi‐technique approaches to elucidate the molecular interactions underlying the biological effects of metallodrugs. On this premise, selected examples are used to illustrate how the information obtained on metal‐based drugs and their respective mechanisms can become relevant for applications in fields other than medicine. For example, some well‐known metallodrugs, which have been shown to bind specific amino acid residues of proteins, can be used to solve problems related to protein structure elucidation in crystallographic studies. Diruthenium tetraacetate can be used to catalyze the conversion of hydroxylamines to nitrones with a high selectivity when bound to lysozyme. Finally, a case study is presented in which an unprecedented palladium/arsenic‐mediated catalytic cycle for nitrile hydration was discovered thanks to previous studies on the solution chemistry of the anticancer compound arsenoplatin‐1 (AP‐1). Starting from the description of integrated approaches for unveiling the molecular interactions underlying the biological effects of metallodrugs, through selected examples, it is highlighted how the obtained mechanistic information may turn relevant for the application of inorganic drugs in fields different from medicine.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39158114</pmid><doi>10.1002/chem.202402647</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-5051-1584</orcidid><orcidid>https://orcid.org/0000-0003-4857-9819</orcidid><orcidid>https://orcid.org/0000-0002-4193-7612</orcidid><orcidid>https://orcid.org/0000-0002-8311-8172</orcidid><orcidid>https://orcid.org/0000-0002-9490-8014</orcidid><orcidid>https://orcid.org/0000-0001-9175-9562</orcidid><orcidid>https://orcid.org/0000-0002-9553-9943</orcidid><orcidid>https://orcid.org/0000-0002-2567-3637</orcidid><orcidid>https://orcid.org/0000-0001-9700-5331</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0947-6539
ispartof Chemistry : a European journal, 2024-10, Vol.30 (60), p.e202402647-n/a
issn 0947-6539
1521-3765
1521-3765
language eng
recordid cdi_proquest_miscellaneous_3094472657
source MEDLINE; Access via Wiley Online Library
subjects Amino acids
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Arsenic
Arsenic - chemistry
Arsenic compounds
Biological effects
Cancer
Catalysis
Catalytic converters
Coordination Complexes - chemistry
Crystallography
Drug interaction
Drug repurposing
Drugs
Heavy metals
Humans
Lysozyme
Mass spectrometry
Metallodrugs
Molecular interactions
Muramidase - chemistry
Muramidase - metabolism
Palladium
Palladium - chemistry
Protein structure
Proteins
X-ray crystallography
title Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T14%3A50%3A43IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Non%E2%80%90Medical%20Applications%20of%20Inorganic%20Medicines.%20A%20Switch%20Based%20on%20Mechanistic%20Knowledge&rft.jtitle=Chemistry%20:%20a%20European%20journal&rft.au=Cirri,%20Damiano&rft.date=2024-10-28&rft.volume=30&rft.issue=60&rft.spage=e202402647&rft.epage=n/a&rft.pages=e202402647-n/a&rft.issn=0947-6539&rft.eissn=1521-3765&rft_id=info:doi/10.1002/chem.202402647&rft_dat=%3Cproquest_cross%3E3094472657%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3121164806&rft_id=info:pmid/39158114&rfr_iscdi=true