Progressive multifocal leukoencephalopathy in sarcoidosis successfully treated with pembrolizumab
Progressive multifocal leukoencephalopathy (PML) is a severe, demyelinating disease of the central nervous system caused by JC virus infection. The disease can be seen in sarcoidosis patients without additional risk factors. Here, we present an individual with PML secondary to sarcoidosis treated wi...
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| Veröffentlicht in: | Journal of neurovirology 2024-08, Vol.30 (4), p.441-444 |
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| creator | Öztürk, Gizem Tekeli, Elif İrem Erdoğan, Seyda Peker, Elif Yücesan, Canan |
| description | Progressive multifocal leukoencephalopathy (PML) is a severe, demyelinating disease of the central nervous system caused by
JC virus
infection. The disease can be seen in sarcoidosis patients without additional risk factors. Here, we present an individual with PML secondary to sarcoidosis treated with 8 doses of pembrolizumab, a Programmed Cell-Death-1 (PD-1) Immune Checkpoint Inhibitor who showed significant improvement. This report illustrates the objective clinical and radiological improvement in a patient with PML due to sarcoidosis, and suggests further study of immune checkpoint inhibitors as a potential treatment for sarcoidosis patients with PML. |
| doi_str_mv | 10.1007/s13365-024-01227-6 |
| format | Article |
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JC virus
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JC virus
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JC virus
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| subjects | Antibodies, Monoclonal, Humanized - therapeutic use Biomedical and Life Sciences Biomedicine Case Report Female Humans Immune Checkpoint Inhibitors - therapeutic use Immunology Infectious Diseases JC Virus - drug effects Leukoencephalopathy, Progressive Multifocal - diagnostic imaging Leukoencephalopathy, Progressive Multifocal - drug therapy Leukoencephalopathy, Progressive Multifocal - immunology Leukoencephalopathy, Progressive Multifocal - virology Male Middle Aged Neurology Neurosciences Sarcoidosis - diagnostic imaging Sarcoidosis - drug therapy Treatment Outcome Virology |
| title | Progressive multifocal leukoencephalopathy in sarcoidosis successfully treated with pembrolizumab |
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