Inhibitors of Rickettsia prowazekii methionine aminopeptidase 1 identified from the Pandemic Response Box

[Display omitted] •Nineteen compounds were identified that possessed IC50 values from 10 µM to 340 nM.•The most potent inhibitor was MMV 1580488 (17), which was observed to have an IC50 of 340 nM.•Docking experiments show that the inhibitors are predicted to bind in the S1 pocket and S1′ pockets of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2024-11, Vol.112, p.129931, Article 129931
Hauptverfasser:	Sharma, Ishpriya, Daraji, Drashti, Horn, James R., Hagen, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	MetAp Molecular docking Pandemic Response Box Rickettsia prowazekii Typhus
Online-Zugang:	Volltext
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