The Synergy Factor: Trauma and Cancer
Trauma and cancer are the leading causes of death in the US. There is a paucity of data describing the impact of cancer on trauma patients. We aimed to determine the influence of cancer on outcomes of trauma patients. In this retrospective analysis of American College of Surgeons-Trauma Quality Impr...
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| Veröffentlicht in: | The Journal of surgical research 2024-10, Vol.302, p.393-397 |
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| creator | Alexander, Hunter D. Bhogadi, Sai Krishna Hejazi, Omar Nelson, Adam Khurshid, Muhammad Haris Stewart, Collin Hosseinpour, Hamidreza Colosimo, Christina Magnotti, Louis J. Joseph, Bellal |
| description | Trauma and cancer are the leading causes of death in the US. There is a paucity of data describing the impact of cancer on trauma patients. We aimed to determine the influence of cancer on outcomes of trauma patients.
In this retrospective analysis of American College of Surgeons-Trauma Quality Improvement Program 2019-2021, we included all adult trauma patients (≥18 y) and excluded patients with severe head injuries and nonmelanomatous skin cancers. Patients were stratified into cancer (C), and no cancer (No-C). Propensity score matching (1:3) was performed. Outcomes were complications and mortality.
A matched cohort of 3236 patients (C, 809; No-C, 2427) was analyzed. The mean age was 70 y, 50.5% were males, and the median injury severity score was 8 (4-10). There were no differences in terms of receiving thromboprophylaxis (C 51%: No-C 50%, P = 0.516). Compared to No-C group, the C group had higher rates of deep vein thrombosis (C 1.1% versus No-C 0.3%, P = 0.004), but there was no difference in terms of overall complications. Patients in the C group had higher mortality (C 7.5% versus No-C 2.7%, P |
| doi_str_mv | 10.1016/j.jss.2024.07.066 |
| format | Article |
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In this retrospective analysis of American College of Surgeons-Trauma Quality Improvement Program 2019-2021, we included all adult trauma patients (≥18 y) and excluded patients with severe head injuries and nonmelanomatous skin cancers. Patients were stratified into cancer (C), and no cancer (No-C). Propensity score matching (1:3) was performed. Outcomes were complications and mortality.
A matched cohort of 3236 patients (C, 809; No-C, 2427) was analyzed. The mean age was 70 y, 50.5% were males, and the median injury severity score was 8 (4-10). There were no differences in terms of receiving thromboprophylaxis (C 51%: No-C 50%, P = 0.516). Compared to No-C group, the C group had higher rates of deep vein thrombosis (C 1.1% versus No-C 0.3%, P = 0.004), but there was no difference in terms of overall complications. Patients in the C group had higher mortality (C 7.5% versus No-C 2.7%, P < 0.001).
Trauma patients with cancer have nearly 4 times higher odds of deep vein thrombosis and 3 times higher odds of mortality. Developing pathways specific to cancer patients might be necessary to improve the outcomes of trauma patients with cancer.</description><identifier>ISSN: 0022-4804</identifier><identifier>ISSN: 1095-8673</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2024.07.066</identifier><identifier>PMID: 39153360</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Deep vein thrombosis ; Female ; Humans ; Injury Severity Score ; Male ; Middle Aged ; Neoplasms - complications ; Neoplasms - mortality ; Propensity Score ; Retrospective Studies ; Trauma ; VTE prophylaxis ; Wounds and Injuries - complications ; Wounds and Injuries - mortality</subject><ispartof>The Journal of surgical research, 2024-10, Vol.302, p.393-397</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-7295a04268aa62f20e5ac8439196dbbe4d870cdec5348e66aa5e1a07080546ba3</cites><orcidid>0000-0002-2205-3061</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jss.2024.07.066$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39153360$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alexander, Hunter D.</creatorcontrib><creatorcontrib>Bhogadi, Sai Krishna</creatorcontrib><creatorcontrib>Hejazi, Omar</creatorcontrib><creatorcontrib>Nelson, Adam</creatorcontrib><creatorcontrib>Khurshid, Muhammad Haris</creatorcontrib><creatorcontrib>Stewart, Collin</creatorcontrib><creatorcontrib>Hosseinpour, Hamidreza</creatorcontrib><creatorcontrib>Colosimo, Christina</creatorcontrib><creatorcontrib>Magnotti, Louis J.</creatorcontrib><creatorcontrib>Joseph, Bellal</creatorcontrib><title>The Synergy Factor: Trauma and Cancer</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Trauma and cancer are the leading causes of death in the US. There is a paucity of data describing the impact of cancer on trauma patients. We aimed to determine the influence of cancer on outcomes of trauma patients.
In this retrospective analysis of American College of Surgeons-Trauma Quality Improvement Program 2019-2021, we included all adult trauma patients (≥18 y) and excluded patients with severe head injuries and nonmelanomatous skin cancers. Patients were stratified into cancer (C), and no cancer (No-C). Propensity score matching (1:3) was performed. Outcomes were complications and mortality.
A matched cohort of 3236 patients (C, 809; No-C, 2427) was analyzed. The mean age was 70 y, 50.5% were males, and the median injury severity score was 8 (4-10). There were no differences in terms of receiving thromboprophylaxis (C 51%: No-C 50%, P = 0.516). Compared to No-C group, the C group had higher rates of deep vein thrombosis (C 1.1% versus No-C 0.3%, P = 0.004), but there was no difference in terms of overall complications. Patients in the C group had higher mortality (C 7.5% versus No-C 2.7%, P < 0.001).
Trauma patients with cancer have nearly 4 times higher odds of deep vein thrombosis and 3 times higher odds of mortality. Developing pathways specific to cancer patients might be necessary to improve the outcomes of trauma patients with cancer.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Deep vein thrombosis</subject><subject>Female</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - mortality</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Trauma</subject><subject>VTE prophylaxis</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - mortality</subject><issn>0022-4804</issn><issn>1095-8673</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRbK3-AC-Si-AlcfY70ZMUq0LBg_W8bDZTTWiTupsI_fduafXoaRh43neYh5BLChkFqm6brAkhY8BEBjoDpY7ImEIh01xpfkzGAIylIgcxImchNBD3QvNTMuIFlZwrGJPrxScmb9sW_cc2mVnXd_4uWXg7rG1i2yqZ2tahPycnS7sKeHGYE_I-e1xMn9P569PL9GGeOsZln2pWSAuCqdxaxZYMUFqXi3itUFVZoqhyDa5CJ7nIUSlrJVILGnKQQpWWT8jNvnfju68BQ2_WdXC4WtkWuyEYDoUAITTVEaV71PkuBI9Ls_H12vqtoWB2dkxjoh2zs2NAm2gnZq4O9UO5xuov8asjAvd7AOOT3zV6E1yN0UBVe3S9qbr6n_of96dyeQ</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Alexander, Hunter D.</creator><creator>Bhogadi, Sai Krishna</creator><creator>Hejazi, Omar</creator><creator>Nelson, Adam</creator><creator>Khurshid, Muhammad Haris</creator><creator>Stewart, Collin</creator><creator>Hosseinpour, Hamidreza</creator><creator>Colosimo, Christina</creator><creator>Magnotti, Louis J.</creator><creator>Joseph, Bellal</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2205-3061</orcidid></search><sort><creationdate>202410</creationdate><title>The Synergy Factor: Trauma and Cancer</title><author>Alexander, Hunter D. ; Bhogadi, Sai Krishna ; Hejazi, Omar ; Nelson, Adam ; Khurshid, Muhammad Haris ; Stewart, Collin ; Hosseinpour, Hamidreza ; Colosimo, Christina ; Magnotti, Louis J. ; Joseph, Bellal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-7295a04268aa62f20e5ac8439196dbbe4d870cdec5348e66aa5e1a07080546ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Deep vein thrombosis</topic><topic>Female</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - mortality</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Trauma</topic><topic>VTE prophylaxis</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - mortality</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alexander, Hunter D.</creatorcontrib><creatorcontrib>Bhogadi, Sai Krishna</creatorcontrib><creatorcontrib>Hejazi, Omar</creatorcontrib><creatorcontrib>Nelson, Adam</creatorcontrib><creatorcontrib>Khurshid, Muhammad Haris</creatorcontrib><creatorcontrib>Stewart, Collin</creatorcontrib><creatorcontrib>Hosseinpour, Hamidreza</creatorcontrib><creatorcontrib>Colosimo, Christina</creatorcontrib><creatorcontrib>Magnotti, Louis J.</creatorcontrib><creatorcontrib>Joseph, Bellal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alexander, Hunter D.</au><au>Bhogadi, Sai Krishna</au><au>Hejazi, Omar</au><au>Nelson, Adam</au><au>Khurshid, Muhammad Haris</au><au>Stewart, Collin</au><au>Hosseinpour, Hamidreza</au><au>Colosimo, Christina</au><au>Magnotti, Louis J.</au><au>Joseph, Bellal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Synergy Factor: Trauma and Cancer</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2024-10</date><risdate>2024</risdate><volume>302</volume><spage>393</spage><epage>397</epage><pages>393-397</pages><issn>0022-4804</issn><issn>1095-8673</issn><eissn>1095-8673</eissn><abstract>Trauma and cancer are the leading causes of death in the US. There is a paucity of data describing the impact of cancer on trauma patients. We aimed to determine the influence of cancer on outcomes of trauma patients.
In this retrospective analysis of American College of Surgeons-Trauma Quality Improvement Program 2019-2021, we included all adult trauma patients (≥18 y) and excluded patients with severe head injuries and nonmelanomatous skin cancers. Patients were stratified into cancer (C), and no cancer (No-C). Propensity score matching (1:3) was performed. Outcomes were complications and mortality.
A matched cohort of 3236 patients (C, 809; No-C, 2427) was analyzed. The mean age was 70 y, 50.5% were males, and the median injury severity score was 8 (4-10). There were no differences in terms of receiving thromboprophylaxis (C 51%: No-C 50%, P = 0.516). Compared to No-C group, the C group had higher rates of deep vein thrombosis (C 1.1% versus No-C 0.3%, P = 0.004), but there was no difference in terms of overall complications. Patients in the C group had higher mortality (C 7.5% versus No-C 2.7%, P < 0.001).
Trauma patients with cancer have nearly 4 times higher odds of deep vein thrombosis and 3 times higher odds of mortality. Developing pathways specific to cancer patients might be necessary to improve the outcomes of trauma patients with cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39153360</pmid><doi>10.1016/j.jss.2024.07.066</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2205-3061</orcidid></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Cancer Deep vein thrombosis Female Humans Injury Severity Score Male Middle Aged Neoplasms - complications Neoplasms - mortality Propensity Score Retrospective Studies Trauma VTE prophylaxis Wounds and Injuries - complications Wounds and Injuries - mortality |
| title | The Synergy Factor: Trauma and Cancer |
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