Chimeric peptide-engineered immunostimulant for endoplasmic reticulum targeted photodynamic immunotherapy against metastatic tumor

The combination of therapy-induced immunogenic cell death (ICD) and immune checkpoint blockade can provide a mutually reinforced strategy to reverse the poor immunogenicity and immune escape behavior of tumors. In this work, a chimeric peptide-engineered immunostimulant (ER-PPB) is fabricated for en...

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Veröffentlicht in:	Journal of controlled release 2024-10, Vol.374, p.230-241
Hauptverfasser:	Zheng, Rongrong, Yang, Ni, Li, Qiuyuan, Chen, Zuxiao, Huang, Chuyu, Zhao, Linping, Chen, Xin, Li, Shiying
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Adjuvants, Immunologic - therapeutic use Animals B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology Cell Line, Tumor Endoplasmic Reticulum Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Endoplasmic reticulum targeting Female Humans Immune checkpoint blockade Immunogenic cell death Immunotherapy - methods Mice Mice, Inbred BALB C Mice, Inbred C57BL Neoplasms - immunology Neoplasms - pathology Neoplasms - therapy Peptides - administration & dosage Peptides - chemistry Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - administration & dosage Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Programmed Cell Death 1 Receptor - antagonists & inhibitors Programmed Cell Death 1 Receptor - immunology Protoporphyrins - administration & dosage Protoporphyrins - chemistry
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