Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study
Background The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population. Methods Consecutive subjects who underwent upper endoscopic screening at 17 ce...
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| Veröffentlicht in: | Journal of gastroenterology 2024-10, Vol.59 (10), p.887-895 |
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| creator | Fukuda, Sho Watanabe, Kenta Kubota, Dai Yamamichi, Nobutake Takahashi, Yu Watanabe, Yoshitaka Adachi, Kyoichi Ishimura, Norihisa Koike, Tomoyuki Sugawara, Hideyuki Asanuma, Kiyotaka Abe, Yasuhiko Kon, Takashi Ihara, Eikichi Haraguchi, Kazuhiro Otsuka, Yoshihiro Yoshimura, Rie Iwaya, Yugo Okamura, Takuma Manabe, Noriaki Horiuchi, Akira Matsumoto, Mio Onochi, Kengo Takahashi, So Yoshida, Tatsuki Shimodaira, Yosuke Iijima, Katsunori |
| description | Background
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population.
Methods
Consecutive subjects who underwent upper endoscopic screening at 17 centers between 2013 and 2017 and had at least one follow-up endoscopy by December 2022 were included. The presence/absence of BE and, if present, its length were retrospectively assessed using the retrieved endoscopic images recorded at baseline. Information on the subsequent occurrence of esophageal adenocarcinoma and other upper gastrointestinal cancers was also collected. Cancer incidence was calculated and expressed as %/year.
Results
A total of 33,478 subjects were enrolled, and 17,884 (53.4%), 10,641 (31.8%), 4889 (14.6%), and 64 (0.2%) were diagnosed as absent BE, BE |
| doi_str_mv | 10.1007/s00535-024-02139-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3093595343</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3107312155</sourcerecordid><originalsourceid>FETCH-LOGICAL-c256t-baa3c0a0b396d5ca736834774462d09d84e6ed63c4e16a6a55e987cff69127e03</originalsourceid><addsrcrecordid>eNp9kb9uFDEQhy0EIkfgBSiQJRqaJeO_e6YjJwJEkWigtnze2bsNe_Zie0FHxWvk9fIkcXIBJAoKy5b9zW88-gh5zuA1A2hPMoASqgEu62LCNPwBWTBZr5Th_CFZgJGyYayVR-RJzpcATIBaPiZHwjAFircL8nPlgsdE05C_0vWejhg2ZUtjT09dSljK9a-rTDHHaes2c6ZDoOducgEz0ilO8-jKEMMb6mi4O_0YOqS7eSyDx1Bug7GkmCf0ZfiO1MdtTIXmMnf7p-RR78aMz-73Y_Ll7N3n1Yfm4tP7j6u3F43nSpdm7Zzw4GAtjO6Ud63QSyHbVkrNOzDdUqLGTgsvkWmnnVJolq3ve20YbxHEMXl1yJ1S_DZjLnY3ZI_jWKeIc7YCjFBGCSkq-vIf9DLOKdTfWcGgFYwzpSrFD5Svk-WEvZ3SsHNpbxnYWzP2YMZWM_bOjOW16MV99LzeYfen5LeKCogDkOtT2GD62_s_sTe2Y5tJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3107312155</pqid></control><display><type>article</type><title>Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Fukuda, Sho ; Watanabe, Kenta ; Kubota, Dai ; Yamamichi, Nobutake ; Takahashi, Yu ; Watanabe, Yoshitaka ; Adachi, Kyoichi ; Ishimura, Norihisa ; Koike, Tomoyuki ; Sugawara, Hideyuki ; Asanuma, Kiyotaka ; Abe, Yasuhiko ; Kon, Takashi ; Ihara, Eikichi ; Haraguchi, Kazuhiro ; Otsuka, Yoshihiro ; Yoshimura, Rie ; Iwaya, Yugo ; Okamura, Takuma ; Manabe, Noriaki ; Horiuchi, Akira ; Matsumoto, Mio ; Onochi, Kengo ; Takahashi, So ; Yoshida, Tatsuki ; Shimodaira, Yosuke ; Iijima, Katsunori</creator><creatorcontrib>Fukuda, Sho ; Watanabe, Kenta ; Kubota, Dai ; Yamamichi, Nobutake ; Takahashi, Yu ; Watanabe, Yoshitaka ; Adachi, Kyoichi ; Ishimura, Norihisa ; Koike, Tomoyuki ; Sugawara, Hideyuki ; Asanuma, Kiyotaka ; Abe, Yasuhiko ; Kon, Takashi ; Ihara, Eikichi ; Haraguchi, Kazuhiro ; Otsuka, Yoshihiro ; Yoshimura, Rie ; Iwaya, Yugo ; Okamura, Takuma ; Manabe, Noriaki ; Horiuchi, Akira ; Matsumoto, Mio ; Onochi, Kengo ; Takahashi, So ; Yoshida, Tatsuki ; Shimodaira, Yosuke ; Iijima, Katsunori</creatorcontrib><description>Background
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population.
Methods
Consecutive subjects who underwent upper endoscopic screening at 17 centers between 2013 and 2017 and had at least one follow-up endoscopy by December 2022 were included. The presence/absence of BE and, if present, its length were retrospectively assessed using the retrieved endoscopic images recorded at baseline. Information on the subsequent occurrence of esophageal adenocarcinoma and other upper gastrointestinal cancers was also collected. Cancer incidence was calculated and expressed as %/year.
Results
A total of 33,478 subjects were enrolled, and 17,884 (53.4%), 10,641 (31.8%), 4889 (14.6%), and 64 (0.2%) were diagnosed as absent BE, BE < 1 cm, 1–3 cm, and ≥ 3 cm, respectively. During a median follow-up of 80 months, 11 cases of esophageal adenocarcinoma developed. The annual incidence of esophageal adenocarcinoma is 0%/year for absent BE, 0.0032 (0.00066–0.013)%/year for BE < 1 cm, 0.026 (0.011–0.054)%/year for 1–3 cm, and 0.58 (0.042–2.11)%/year for ≥ 3 cm, respectively. Meanwhile, the incidence of esophageal squamous cell carcinoma and gastric cancer were 0.039 (0.031–0.049)%/year and 0.16 (0.14–0.18)%/year, respectively.
Conclusions
By enrolling a large number of subjects with long-term follow-up, this study demonstrated that the risk of cancer increased steadily with increasing length of BE in the Japanese population. Therefore, it is important to consider the length of BE when determining the management strategy for BE.</description><identifier>ISSN: 0944-1174</identifier><identifier>ISSN: 1435-5922</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-024-02139-2</identifier><identifier>PMID: 39150527</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Abdominal Surgery ; Adenocarcinoma ; Adenocarcinoma - epidemiology ; Adult ; Aged ; Barrett Esophagus - epidemiology ; Barrett's esophagus ; Colorectal Surgery ; East Asian People ; Endoscopy ; Esophageal cancer ; Esophageal carcinoma ; Esophageal Neoplasms - epidemiology ; Esophagoscopy ; Female ; Follow-Up Studies ; Gastric cancer ; Gastroenterology ; Hepatology ; Humans ; Incidence ; Japan - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article—Alimentary Tract ; Population studies ; Retrospective Studies ; Risk Factors ; Squamous cell carcinoma ; Surgical Oncology</subject><ispartof>Journal of gastroenterology, 2024-10, Vol.59 (10), p.887-895</ispartof><rights>Japanese Society of Gastroenterology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Japanese Society of Gastroenterology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c256t-baa3c0a0b396d5ca736834774462d09d84e6ed63c4e16a6a55e987cff69127e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-024-02139-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-024-02139-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39150527$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fukuda, Sho</creatorcontrib><creatorcontrib>Watanabe, Kenta</creatorcontrib><creatorcontrib>Kubota, Dai</creatorcontrib><creatorcontrib>Yamamichi, Nobutake</creatorcontrib><creatorcontrib>Takahashi, Yu</creatorcontrib><creatorcontrib>Watanabe, Yoshitaka</creatorcontrib><creatorcontrib>Adachi, Kyoichi</creatorcontrib><creatorcontrib>Ishimura, Norihisa</creatorcontrib><creatorcontrib>Koike, Tomoyuki</creatorcontrib><creatorcontrib>Sugawara, Hideyuki</creatorcontrib><creatorcontrib>Asanuma, Kiyotaka</creatorcontrib><creatorcontrib>Abe, Yasuhiko</creatorcontrib><creatorcontrib>Kon, Takashi</creatorcontrib><creatorcontrib>Ihara, Eikichi</creatorcontrib><creatorcontrib>Haraguchi, Kazuhiro</creatorcontrib><creatorcontrib>Otsuka, Yoshihiro</creatorcontrib><creatorcontrib>Yoshimura, Rie</creatorcontrib><creatorcontrib>Iwaya, Yugo</creatorcontrib><creatorcontrib>Okamura, Takuma</creatorcontrib><creatorcontrib>Manabe, Noriaki</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Matsumoto, Mio</creatorcontrib><creatorcontrib>Onochi, Kengo</creatorcontrib><creatorcontrib>Takahashi, So</creatorcontrib><creatorcontrib>Yoshida, Tatsuki</creatorcontrib><creatorcontrib>Shimodaira, Yosuke</creatorcontrib><creatorcontrib>Iijima, Katsunori</creatorcontrib><title>Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population.
Methods
Consecutive subjects who underwent upper endoscopic screening at 17 centers between 2013 and 2017 and had at least one follow-up endoscopy by December 2022 were included. The presence/absence of BE and, if present, its length were retrospectively assessed using the retrieved endoscopic images recorded at baseline. Information on the subsequent occurrence of esophageal adenocarcinoma and other upper gastrointestinal cancers was also collected. Cancer incidence was calculated and expressed as %/year.
Results
A total of 33,478 subjects were enrolled, and 17,884 (53.4%), 10,641 (31.8%), 4889 (14.6%), and 64 (0.2%) were diagnosed as absent BE, BE < 1 cm, 1–3 cm, and ≥ 3 cm, respectively. During a median follow-up of 80 months, 11 cases of esophageal adenocarcinoma developed. The annual incidence of esophageal adenocarcinoma is 0%/year for absent BE, 0.0032 (0.00066–0.013)%/year for BE < 1 cm, 0.026 (0.011–0.054)%/year for 1–3 cm, and 0.58 (0.042–2.11)%/year for ≥ 3 cm, respectively. Meanwhile, the incidence of esophageal squamous cell carcinoma and gastric cancer were 0.039 (0.031–0.049)%/year and 0.16 (0.14–0.18)%/year, respectively.
Conclusions
By enrolling a large number of subjects with long-term follow-up, this study demonstrated that the risk of cancer increased steadily with increasing length of BE in the Japanese population. Therefore, it is important to consider the length of BE when determining the management strategy for BE.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Barrett Esophagus - epidemiology</subject><subject>Barrett's esophagus</subject><subject>Colorectal Surgery</subject><subject>East Asian People</subject><subject>Endoscopy</subject><subject>Esophageal cancer</subject><subject>Esophageal carcinoma</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophagoscopy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article—Alimentary Tract</subject><subject>Population studies</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Squamous cell carcinoma</subject><subject>Surgical Oncology</subject><issn>0944-1174</issn><issn>1435-5922</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kb9uFDEQhy0EIkfgBSiQJRqaJeO_e6YjJwJEkWigtnze2bsNe_Zie0FHxWvk9fIkcXIBJAoKy5b9zW88-gh5zuA1A2hPMoASqgEu62LCNPwBWTBZr5Th_CFZgJGyYayVR-RJzpcATIBaPiZHwjAFircL8nPlgsdE05C_0vWejhg2ZUtjT09dSljK9a-rTDHHaes2c6ZDoOducgEz0ilO8-jKEMMb6mi4O_0YOqS7eSyDx1Bug7GkmCf0ZfiO1MdtTIXmMnf7p-RR78aMz-73Y_Ll7N3n1Yfm4tP7j6u3F43nSpdm7Zzw4GAtjO6Ud63QSyHbVkrNOzDdUqLGTgsvkWmnnVJolq3ve20YbxHEMXl1yJ1S_DZjLnY3ZI_jWKeIc7YCjFBGCSkq-vIf9DLOKdTfWcGgFYwzpSrFD5Svk-WEvZ3SsHNpbxnYWzP2YMZWM_bOjOW16MV99LzeYfen5LeKCogDkOtT2GD62_s_sTe2Y5tJ</recordid><startdate>20241001</startdate><enddate>20241001</enddate><creator>Fukuda, Sho</creator><creator>Watanabe, Kenta</creator><creator>Kubota, Dai</creator><creator>Yamamichi, Nobutake</creator><creator>Takahashi, Yu</creator><creator>Watanabe, Yoshitaka</creator><creator>Adachi, Kyoichi</creator><creator>Ishimura, Norihisa</creator><creator>Koike, Tomoyuki</creator><creator>Sugawara, Hideyuki</creator><creator>Asanuma, Kiyotaka</creator><creator>Abe, Yasuhiko</creator><creator>Kon, Takashi</creator><creator>Ihara, Eikichi</creator><creator>Haraguchi, Kazuhiro</creator><creator>Otsuka, Yoshihiro</creator><creator>Yoshimura, Rie</creator><creator>Iwaya, Yugo</creator><creator>Okamura, Takuma</creator><creator>Manabe, Noriaki</creator><creator>Horiuchi, Akira</creator><creator>Matsumoto, Mio</creator><creator>Onochi, Kengo</creator><creator>Takahashi, So</creator><creator>Yoshida, Tatsuki</creator><creator>Shimodaira, Yosuke</creator><creator>Iijima, Katsunori</creator><general>Springer Nature Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241001</creationdate><title>Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study</title><author>Fukuda, Sho ; Watanabe, Kenta ; Kubota, Dai ; Yamamichi, Nobutake ; Takahashi, Yu ; Watanabe, Yoshitaka ; Adachi, Kyoichi ; Ishimura, Norihisa ; Koike, Tomoyuki ; Sugawara, Hideyuki ; Asanuma, Kiyotaka ; Abe, Yasuhiko ; Kon, Takashi ; Ihara, Eikichi ; Haraguchi, Kazuhiro ; Otsuka, Yoshihiro ; Yoshimura, Rie ; Iwaya, Yugo ; Okamura, Takuma ; Manabe, Noriaki ; Horiuchi, Akira ; Matsumoto, Mio ; Onochi, Kengo ; Takahashi, So ; Yoshida, Tatsuki ; Shimodaira, Yosuke ; Iijima, Katsunori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-baa3c0a0b396d5ca736834774462d09d84e6ed63c4e16a6a55e987cff69127e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Barrett Esophagus - epidemiology</topic><topic>Barrett's esophagus</topic><topic>Colorectal Surgery</topic><topic>East Asian People</topic><topic>Endoscopy</topic><topic>Esophageal cancer</topic><topic>Esophageal carcinoma</topic><topic>Esophageal Neoplasms - epidemiology</topic><topic>Esophagoscopy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article—Alimentary Tract</topic><topic>Population studies</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Squamous cell carcinoma</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fukuda, Sho</creatorcontrib><creatorcontrib>Watanabe, Kenta</creatorcontrib><creatorcontrib>Kubota, Dai</creatorcontrib><creatorcontrib>Yamamichi, Nobutake</creatorcontrib><creatorcontrib>Takahashi, Yu</creatorcontrib><creatorcontrib>Watanabe, Yoshitaka</creatorcontrib><creatorcontrib>Adachi, Kyoichi</creatorcontrib><creatorcontrib>Ishimura, Norihisa</creatorcontrib><creatorcontrib>Koike, Tomoyuki</creatorcontrib><creatorcontrib>Sugawara, Hideyuki</creatorcontrib><creatorcontrib>Asanuma, Kiyotaka</creatorcontrib><creatorcontrib>Abe, Yasuhiko</creatorcontrib><creatorcontrib>Kon, Takashi</creatorcontrib><creatorcontrib>Ihara, Eikichi</creatorcontrib><creatorcontrib>Haraguchi, Kazuhiro</creatorcontrib><creatorcontrib>Otsuka, Yoshihiro</creatorcontrib><creatorcontrib>Yoshimura, Rie</creatorcontrib><creatorcontrib>Iwaya, Yugo</creatorcontrib><creatorcontrib>Okamura, Takuma</creatorcontrib><creatorcontrib>Manabe, Noriaki</creatorcontrib><creatorcontrib>Horiuchi, Akira</creatorcontrib><creatorcontrib>Matsumoto, Mio</creatorcontrib><creatorcontrib>Onochi, Kengo</creatorcontrib><creatorcontrib>Takahashi, So</creatorcontrib><creatorcontrib>Yoshida, Tatsuki</creatorcontrib><creatorcontrib>Shimodaira, Yosuke</creatorcontrib><creatorcontrib>Iijima, Katsunori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fukuda, Sho</au><au>Watanabe, Kenta</au><au>Kubota, Dai</au><au>Yamamichi, Nobutake</au><au>Takahashi, Yu</au><au>Watanabe, Yoshitaka</au><au>Adachi, Kyoichi</au><au>Ishimura, Norihisa</au><au>Koike, Tomoyuki</au><au>Sugawara, Hideyuki</au><au>Asanuma, Kiyotaka</au><au>Abe, Yasuhiko</au><au>Kon, Takashi</au><au>Ihara, Eikichi</au><au>Haraguchi, Kazuhiro</au><au>Otsuka, Yoshihiro</au><au>Yoshimura, Rie</au><au>Iwaya, Yugo</au><au>Okamura, Takuma</au><au>Manabe, Noriaki</au><au>Horiuchi, Akira</au><au>Matsumoto, Mio</au><au>Onochi, Kengo</au><au>Takahashi, So</au><au>Yoshida, Tatsuki</au><au>Shimodaira, Yosuke</au><au>Iijima, Katsunori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2024-10-01</date><risdate>2024</risdate><volume>59</volume><issue>10</issue><spage>887</spage><epage>895</epage><pages>887-895</pages><issn>0944-1174</issn><issn>1435-5922</issn><eissn>1435-5922</eissn><abstract>Background
The cancer risk for each length of Barrett’s esophagus (BE) in Japanese is unknown. This nationwide, multi-institutional study aims to clarify the cancer risk by length of BE in the general Japanese population.
Methods
Consecutive subjects who underwent upper endoscopic screening at 17 centers between 2013 and 2017 and had at least one follow-up endoscopy by December 2022 were included. The presence/absence of BE and, if present, its length were retrospectively assessed using the retrieved endoscopic images recorded at baseline. Information on the subsequent occurrence of esophageal adenocarcinoma and other upper gastrointestinal cancers was also collected. Cancer incidence was calculated and expressed as %/year.
Results
A total of 33,478 subjects were enrolled, and 17,884 (53.4%), 10,641 (31.8%), 4889 (14.6%), and 64 (0.2%) were diagnosed as absent BE, BE < 1 cm, 1–3 cm, and ≥ 3 cm, respectively. During a median follow-up of 80 months, 11 cases of esophageal adenocarcinoma developed. The annual incidence of esophageal adenocarcinoma is 0%/year for absent BE, 0.0032 (0.00066–0.013)%/year for BE < 1 cm, 0.026 (0.011–0.054)%/year for 1–3 cm, and 0.58 (0.042–2.11)%/year for ≥ 3 cm, respectively. Meanwhile, the incidence of esophageal squamous cell carcinoma and gastric cancer were 0.039 (0.031–0.049)%/year and 0.16 (0.14–0.18)%/year, respectively.
Conclusions
By enrolling a large number of subjects with long-term follow-up, this study demonstrated that the risk of cancer increased steadily with increasing length of BE in the Japanese population. Therefore, it is important to consider the length of BE when determining the management strategy for BE.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>39150527</pmid><doi>10.1007/s00535-024-02139-2</doi><tpages>9</tpages></addata></record> |
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| ispartof | Journal of gastroenterology, 2024-10, Vol.59 (10), p.887-895 |
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| subjects | Abdominal Surgery Adenocarcinoma Adenocarcinoma - epidemiology Adult Aged Barrett Esophagus - epidemiology Barrett's esophagus Colorectal Surgery East Asian People Endoscopy Esophageal cancer Esophageal carcinoma Esophageal Neoplasms - epidemiology Esophagoscopy Female Follow-Up Studies Gastric cancer Gastroenterology Hepatology Humans Incidence Japan - epidemiology Male Medicine Medicine & Public Health Middle Aged Original Article—Alimentary Tract Population studies Retrospective Studies Risk Factors Squamous cell carcinoma Surgical Oncology |
| title | Cancer risk by length of Barrett’s esophagus in Japanese population: a nationwide multicenter retrospective cohort study |
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