ARNTL2 facilitates bladder cancer progression through potentiating ENO1-mediated glycolysis in a SLC31A1-independent and -dependent manner

Basic helix-loop-helix ARNT like 2 (ARNTL2) is a transcription factor that controls the circadian rhythm. Amounts of studies have demonstrated the carcinogenic function of ARNTL2 in human malignant tumors albeit the underlying mechanisms remain poorly understood. We aimed to study the significance o...

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Veröffentlicht in:	Life sciences (1973) 2024-10, Vol.355, p.122974, Article 122974
Hauptverfasser:	Wang, Jiahao, Ren, Junwei, Tu, Xiang, Yuan, Haichao, Ye, Zhenyang, Wang, Xiaoming, Cui, Jianwei, Wang, Jia, Tang, Yin, Han, Ping, Bai, Yunjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism ARNTL2 Biomarkers, Tumor BLCA Carcinogenesis - genetics Carcinogenesis - metabolism Cell Line, Tumor Cell Proliferation Disease Progression DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism ENO1 Female Gene Expression Regulation, Neoplastic Glycolysis Humans Male Mice Mice, Inbred BALB C Mice, Nude Phosphopyruvate Hydratase - genetics Phosphopyruvate Hydratase - metabolism SLC31A1 Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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