Activation of angiotensin II type 2 receptor leads to preservation of primary cilia in tubular cells during renal ischaemia‐reperfusion injury

Ischaemia‐reperfusion (IR)‐associated acute kidney injury (AKI) is a severe clinical condition that lacks effective pharmacological treatments. Our recent research revealed that pretreatment with the angiotensin II type 2 receptor (AT2R) agonist C21 alleviates kidney damage during IR. Primary cilia...

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Veröffentlicht in:	The Journal of physiology 2024-10, Vol.602 (19), p.5083-5103
Hauptverfasser:	Maknis, Tomás Rivabella, Fussi, M. Fernanda, Pariani, Alejandro P., Huhn, Victoria, Vena, Rodrigo, Favre, Cristián, Molinas, Sara M., Larocca, M. Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylated α‐tubulin Acetylation Agonists Angiotensin AT2 receptors Angiotensin II Cell activation Cell death Cilia cilia stability compound C21 Deacetylation Drug therapy Epithelial cells ERK1/2 Extracellular signal-regulated kinase Homeostasis Immunofluorescence Ischemia Kidneys Localization Organelles Phosphorylation Preservation Reperfusion Tubulin
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