Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11

Nonalcoholic fatty liver disease (NAFLD), including its more severe manifestation nonalcoholic steatohepatitis (NASH), is a global public health challenge. Here, we explore the role of deubiquitinating enzyme RPN11 in NAFLD and NASH. Hepatocyte-specific RPN11 knockout mice are protected from diet-in...

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Veröffentlicht in:	Cell metabolism 2024-10, Vol.36 (10), p.2228-2244.e7
Hauptverfasser:	Zhou, Bing, Luo, Yunchen, Bi, Hanqi, Zhang, Ni, Ma, Mingyue, Dong, Zhixia, Ji, Nana, Zhang, Shuo, Wang, Xiaoye, Liu, Yuejun, Guo, Xiaozhen, Wei, Wei, Xie, Cen, Wu, Ling, Wan, Xinjian, Zheng, Ming-Hua, Zhao, Bing, Li, Yao, Hu, Cheng, Lu, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deubiquitinating Enzymes - antagonists & inhibitors Deubiquitinating Enzymes - metabolism deubiquitination Hepatocytes - metabolism histone propionylation Humans Lipid Metabolism - drug effects Male Mice Mice, Inbred C57BL Mice, Knockout N6-methyladenosine methylation Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology nonalcoholic fatty liver disease nonalcoholic steatohepatitis Proteasome Endopeptidase Complex - metabolism Trans-Activators - metabolism Ubiquitination
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