Gene network analysis combined with preclinical studies to identify and elucidate the mechanism of action of novel irreversible Keap1 inhibitor for Parkinson's disease

The cysteine residues of Keap1 such as C151, C273, and C288 are critical for its repressor activity on Nrf2. However, to date, no molecules have been identified to covalently modify all three cysteine residues for Nrf2 activation. Hence, in this study, our goal is to discover new Keap1 covalent inhi...

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Veröffentlicht in:	Molecular diversity 2024-08
Hauptverfasser:	Arumugam, Monisha, Pachamuthu, Ranjith Sanjeeve, Rymbai, Emdormi, Jha, Aditya Prakash, Rajagopal, Kalirajan, Kothandan, Ram, Muthu, Santhoshkumar, Selvaraj, Divakar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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