Zika virus NS5 protein inhibits type I interferon signaling via CRL3 E3 ubiquitin ligase-mediated degradation of STAT2

The ZIKA virus (ZIKV) evades the host immune response by degrading STAT2 through its NS5 protein, thereby inhibiting type I interferon (IFN)-mediated antiviral immunity. However, the molecular mechanism underlying this process has remained elusive. In this study, we performed a genome-wide CRISPR/Ca...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-08, Vol.121 (34), p.e2403235121
Hauptverfasser:	Ren, Wenlin, Fu, Chonglei, Zhang, Yu, Ju, Xiaohui, Jiang, Xi, Song, Jingwei, Gong, Mingli, Li, Zhuoyang, Fan, Wenchun, Yao, Jun, Ding, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Antiviral agents Biochemical analysis Cell activation Cells (biology) CRISPR CRISPR-Cas Systems Cullin Proteins - metabolism Degradation Depletion HEK293 Cells Humans Immune response Immune system Interferon Interferon Type I - metabolism Molecular modelling Neural stem cells NS5 protein Progenitor cells Proteasomes Proteins Proteolysis Signal Transduction Stat2 protein STAT2 Transcription Factor - metabolism Substrates Ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Vector-borne diseases Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Zika virus Zika Virus - immunology Zika Virus - metabolism Zika Virus - physiology Zika Virus Infection - immunology Zika Virus Infection - metabolism Zika Virus Infection - virology
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