Genome‐wide study identifies novel genes associated with bone toxicities in children with acute lymphoblastic leukaemia

Summary Bone toxicities are common among paediatric patients treated for acute lymphoblastic leukaemia (ALL) with potentially major negative impact on patients' quality of life. To identify the underlying genetic contributors, we conducted a genome‐wide association study (GWAS) and a transcript...

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Veröffentlicht in:	British journal of haematology 2024-11, Vol.205 (5), p.1889-1898
Hauptverfasser:	Zhu, Qianqian, Nambiar, Ram, Schultz, Emily, Gao, Xinyu, Liang, Shuyi, Flamand, Yael, Stevenson, Kristen, Cole, Peter D., Gennarini, Lisa, Harris, Marian H., Kahn, Justine M., Ladas, Elena J., Athale, Uma H., Hoa Tran, Thai, Michon, Bruno, Welch, Jennifer J. G., Sallan, Stephen E., Silverman, Lewis B., Kelly, Kara M., Yao, Song
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute lymphoblastic leukemia Adolescent bone toxicities Child Child, Preschool Chromosome 20 CLINICAL TRIALS Female Fractures Fractures, Bone - chemically induced Fractures, Bone - genetics Genome-wide association studies Genome-Wide Association Study Genomes Humans Leukemia Male Patients Pediatrics Polymorphism, Single Nucleotide Population genetics Population studies Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Quality of life Quantitative Trait Loci Transcriptomes Ultrasound
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