Extracellular vesicle-derived biomarkers in prostate cancer care: Opportunities and challenges

Prostate cancer (PCa) is the second most prevalent cancer in men worldwide, presenting a significant global public health challenge that necessitates early detection and personalized treatment. Recently, non-invasive liquid biopsy methods have emerged as promising tools to provide insights into the genetic landscape of PCa and monitor disease progression, aiding decision-making at all stages. Research efforts have concentrated on identifying liquid biopsy biomarkers to improve PCa diagnosis, prognosis, and treatment prediction. This article reviews recent research advances over the last five years utilizing extracellular vesicles (EVs) as a natural biomarker library for PCa, and discusses the clinical translation of EV biomarkers, including ongoing trials and key implementation challenges. The findings underscore the transformative role of liquid biopsy, particularly EV-based biomarkers, in revolutionizing PCa diagnosis, prediction, and treatment. •EVs provide non-invasive, reliable biomarkers for PCa liquid biopsy.•Beyond mRNAs, miRNAs, and proteins, Other EV molecules exhibit promising biomarker potential for PCa.•Well-designed multicentre trials are crucial to comfirm the effectiveness of EV-based liquid biopsies for PCa management.