Dual‐Functional Implant Based on Gellan‐Xanthan Hydrogel with Diopside, BMP‐2 and Lysostaphin for Bone Defect Repair and Control of Staphylococcal Infection

A new dual‐functional implant based on gellan‐xanthan hydrogel with calcium‐magnesium silicate ceramic diopside and recombinant lysostaphin and bone morphogenetic protein 2 (BMP‐2)‐ray is developed. In this composite, BMP‐2 is immobilized on microparticles of diopside while lysostaphin is mixed dire...

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Veröffentlicht in:	Macromolecular bioscience 2024-11, Vol.24 (11), p.e2400205-n/a
Hauptverfasser:	Karyagina, Anna S., Grishin, Alexander V., Kudinova, Alina G., Bulygina, Inna N., Koudan, Elizaveta V., Orlova, Polina A., Datsenko, Vera P., Zhulina, Anna V., Grunina, Tatyana M., Poponova, Maria S., Krivozubov, Mikhail S., Gromova, Maria S., Strukova, Natalia V., Generalova, Maria S., Nikitin, Kirill E., Shchetinin, Igor V., Luchnikov, Lev O., Zaitseva, Svetlana V., Kirsanova, Maria A., Statnik, Eugene S., Senatov, Fedor S., Lunin, Vladimir G., Gromov, Alexander V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial activity Biocompatibility Biofilms Biofilms - drug effects BMP‐2 Bone growth Bone implants Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - chemistry Bone Morphogenetic Protein 2 - pharmacology Bone morphogenetic proteins Bone Regeneration - drug effects Calcium magnesium silicates Controlled release Defects Diopside Gellan gum gellan‐xanthan hydrogel Humans Hydrogels Hydrogels - chemistry Hydrogels - pharmacology implant Lysostaphin Lysostaphin - chemistry Lysostaphin - pharmacology Magnesium silicates Mechanical properties Mice Microparticles Osteogenesis Osteogenesis - drug effects Osteomyelitis Planktonic cells Polysaccharides, Bacterial - chemistry Polysaccharides, Bacterial - pharmacology Staphylococcal Infections - drug therapy Staphylococcus aureus Staphylococcus aureus - drug effects Surgical implants Sustained release Transplants & implants Xanthan
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